Award Abstract #0103473
NIRT: Biologically Based Assemblies of Electronic Materials at the Nanoscale; Improving on Nature

NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Initial Amendment Date:	August 22, 2001
Latest Amendment Date:	February 17, 2005
Award Number:	0103473
Award Instrument:	Continuing grant
Program Manager:	Judy A. Raper CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering
Start Date:	September 1, 2001
Expires:	August 31, 2005 (Estimated)
Awarded Amount to Date:	$1500000
Investigator(s):	Angela Belcher belcher@mit.edu (Principal Investigator) Karen Browning (Co-Principal Investigator) Brian Korgel (Co-Principal Investigator)
Sponsor:	University of Texas at Austin P.O Box 7726 Austin, TX 78713 512/471-6424
NSF Program(s):	SPECIAL PROJECTS - CCF, SOLID STATE & MATERIALS CHEMIS, NANOSCALE: INTRDISCPL RESRCH T, ELECT, PHOTONICS, & DEVICE TEC, PARTICULATE &MULTIPHASE PROCES, BIOCHEMICAL & BIOMASS ENG
Field Application(s):	0308000 Industrial Technology
Program Reference Code(s):	OTHR, AMPP, 9162, 1674, 0000
Program Element Code(s):	2878, 1762, 1674, 1517, 1415, 1402

ABSTRACT

Abstract

CTS-0103473

Angela Belcher, University of Texas Austin

This proposal was received in response to Nanoscale Science and Engineering (NSE) solicitation, NSF-00119, in the category Nanoscale Interdisciplinary Research Teams (NIRT).

Biological systems efficiently and accurately assemble nanoscale building blocks into complex

and functionally sophisticated structures with high perfection, controlled size and compositional

uniformity. The self-organizing processes found in these systems rely largely on non-covalent interactions that enable elegant rearrangement between usable architectural forms and self-correction. The research will take advantage of the atomic composition and plane specific recognition that a biomolecule can exhibit for an inorganic phase, and the nanostructural control and regularity that biomolecules typically impose on crystal phases and crystallographic orientations to control nanostructure formation. Furthermore, RNA templates will be used to direct the parallel self-assembly of multiple electronic components with high precision. Using combinatorial peptide evolution, peptide sequences will be identified that select for and bind to specific nanocrystal and nanowire substrates, such as magnetic and semiconductor quantum dots and silicon nanowires synthesized in solution. The peptides provide recognition specificity between the biological molecules and the inorganic substrate. The peptides couple the inorganic electronic "building blocks" to the biological machinery that directs the architectural "blueprints" for organization. In essence, genetically encoding biological-electronic interactions are selecting the mRNA sequences that code for specific amino acid sequences, but beyond that, specific secondary and ultimately tertiary structures can be achieved; thus, leading to supermolecular architectures.

An interdisciplinary effort will include synthetic chemistry, electrical and materials engineering, and molecular biology, which targets the development of specific recognition chemistries between biological and inorganic substrates for the creation of nanostructured materials and devices with novel applications. The proposed project offers highly interdisciplinary educational and research opportunities for graduate students.

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