Award Abstract #0133594
PECASE: Intracellular Signaling Networks in the Immune Response

NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Initial Amendment Date:	January 24, 2002
Latest Amendment Date:	November 13, 2005
Award Number:	0133594
Award Instrument:	Continuing grant
Program Manager:	Bruce K. Hamilton CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering
Start Date:	February 15, 2002
Expires:	July 31, 2007 (Estimated)
Awarded Amount to Date:	$375000
Investigator(s):	Jason Haugh jason_haugh@ncsu.edu (Principal Investigator)
Sponsor:	North Carolina State University CAMPUS BOX 7514 RALEIGH, NC 27695 919/515-2444
NSF Program(s):	BIOCHEMICAL & BIOMASS ENG
Field Application(s):	0308000 Industrial Technology
Program Reference Code(s):	BIOT, 9181, 1187, 1076, 1045
Program Element Code(s):	1402

ABSTRACT



Proposal Title: PECASE: Intracellular Signaling Networks in the Immune Response

Institution: North Carolina State University

The objective of the proposed research is to study T lymphocyte (T cell) regulation at the intracellular level, with a focus on molecular signaling processes initiated by the cell surface receptors for the cytocines, interleukins (IL)-2 and (IL)-4. The specific objectives of this research include: (1) the quantitative analysis of pathway crosstalk interactions in IL-2 receptor signaling, using interventions that target specific intracellular molecules, (2) the characterization of the cooperation of IL-2 receptor-mediated signaling pathways in mediating T cell life (proliferation) and death (apoptosis) decision making, and (3) the elucidation of the synergistic effect of IL-2 and IL-4 on T cell expansion at the level of signaling network interactions. This research could provide new information to help modulate cell function, with potential application being the elucidation of therapeutic strategies.

This project was originally funded as a CAREER award, and was converted to a Presidential Early Career Award for Engineers and Scientists (PECASE) award in May 2004.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

Barua, D., Faeder, J.R., and Haugh, J.M.. "Structure-based kinetic models of modular signaling protein function: focus on Shp2," Biophysical Journal, v.92, 2007, p. 2290.

Haugh, J.M.. "Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists," Biotechnology Progress, v.20, 2004, p. 1337.

Haugh, J.M.. "Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing," Biophysical Journal, v.90, 2006, p. 2297.

Haugh, J.M.. "Localization of receptor-mediated signal transduction pathways: the inside story," Molecular Interventions, v.2, 2002, p. 292.

Schneider, I.C. and Haugh, J.M.. "Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulation," Cell Cycle, v.5, 2006, p. 1130.

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