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Award Abstract #0134476
PECASE:Development of Bioactive Implants Using Calcium Phosphate Nanopowders.
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
January 8, 2002 |
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| Latest Amendment Date: |
October 1, 2007 |
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| Award Number: |
0134476 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Marc S. Ingber
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
January 15, 2002 |
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| Expires: |
December 31, 2008 (Estimated) |
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| Awarded Amount to Date: |
$422500 |
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| Investigator(s): |
Susmita Bose sbose@wsu.edu (Principal Investigator)
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| Sponsor: |
Washington State University
NEILL HALL, ROOM 423
PULLMAN, WA 99164 509/335-9661
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| NSF Program(s): |
PARTICULATE &MULTIPHASE PROCES
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| Field Application(s): |
0308000 Industrial Technology
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| Program Reference Code(s): |
SMET, OTHR, 9251, 9231, 9178, 1187, 1076, 1045, 055E, 0000
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| Program Element Code(s): |
1415
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ABSTRACT
Proposal Title: PECASE: Development of Bioactive Implants using Calcium Phosphate Nanopowders.
Institution: Washington State University
The PI proposes to investigate the synthesis of calcium phosphate based ceramic nano-podwers and its use in the development of bioactive bone implants of improved mechanical properties.
The proposal includes a very well planned /structured research plan addressing key aspects from the synthesis of the material (nanopowders) to processing of various composites for implants, to the detailed physical/mechanical and biological characterization.
The proposal brings a variety of skills to the project, all very well integrated. An entire interdisciplinary program/plan seems to be associated with this proposal. The PI is a very active outstanding young faculty who has a multidisciplinary background, interacts with researchers with various backgrounds and expertise, and is an expert herself on the main experimental techniques to be used within the proposed research activities.
The research questions address in the research plan are highly relevant and the approaches are novel. The proposed level of characterization of mechanical properties of the implant materials/scaffolding materials is consistent with the current needs of the tissue-engineering field. The results of this investigation may significantly contribute to the advancement in the development of scaffolds for bone tissue engineering.
This project was originally funded as a CAREER award, and was converted to a Presidential Early Career Award for Engineers and Scientists (PECASE) award in May 2004.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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(Showing: 1 - 15 of 15)
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A Banerjee and S. Bose. "Effect of Synthesis Parameters on Nanocrystalline PZT Powder," Ceramic Transactions (CT) Volume 167, In symposium on ?Developments in Dielectric Materials and Electronic Devices?,, 2004, p. pp 31-39.
A. Banerjee and S. Bose. "Free-standing lead zirconate titanate Nanoparticles: Low temperature synthesis and densification," Chemistry of Materials, v.16 (26), 2004, p. pp 5610.
A. Banerjee and S. Bose. "Effect of Dopants on The Properties of Nanocrystalline Hydroxyapatite," Ceramic Transaction (CT), In symposium on ?Bioceramics: Materials and Applications V", v.164, 2004, p. pp 91-99.
A. Banerjee, A. Bandyopadhyay and S. Bose. "Effect of ZnO Doping in PZT Nanopowders," Ceramic Transactions (CT)In symposium on "Ceramic Nanomaterials and Nanotechnology III", v.159, 2004, p. pp. 47-54.
S. Bose and A. Banerjee. ""Novel Synthesis Route to Make Nanocrystalline Lead Zirconate Titanate Powder",," Journal of the American Ceramic Society,, v.87[3], 2004, p. 487.
S. Bose and S. K. Saha. ""Synthesis of hydroxyapatite nanopowder using sucrose templated sol-gel method"," Journal of the American Ceramic Society, v.86 [6],, 2003, p. 1055-57.
S. Bose and S. K. Saha. ""Synthesis and characterization of hydroxyapatite nanopowders by emulsion technique",," Chemistry of Materials, v.15 (23), 2003, p. 4464-4469.
S. Bose and Y. Wu. "Synthesis of Al2O3-CeO2 Mixed Oxide nano-powders," Journal of the American Ceramic Society, v.88[7], 2005, p. 1999-2002.
S. Bose, A. Banerjee and A. Bandyopadhyay. "Nanoscale Hydroxyapatite For Bone Implants," Proceedings of the 4th International Symposium on Nano Manufacturing, MIT Press, MIT, MA, 2006, 2006, p. 150.
S. Bose, S. Dasgupta, W. Xue, and A. Bandopadhayay. "Tricalcium Phosphate Nanoparticles: Osteoblast Response and A Novel Drug Carrier," Proceedings of the 4th International Symposium on Nano Manufacturing, MIT Press, MIT, MA, 2006. (Outstanding Paper Award), 2006, p. 240.
S. Bose, S. Dasgupta, W. Xue, and A. Bandopadhayay. "Tricalcium Phosphate Nanoparticles: Osteoblast Response and A Novel Drug Carrier," Proceedings of the 4th International Symposium on Nano Manufacturing, MIT Press, MIT, MA, 2006. (Outstanding Paper Awar, 2006.
Weichang Xue, Amit Bandyopadhyay, Susmita Bose. "Synthesis and characterization of mesoporous calcium silicate for controlled release of protein," in press Acta Biomater (2009), doi:10.1016/j.actbio.2009.01.012, 2009.
Weichang Xue, Kelly Dahlquist, Ashis Banerjee, A. Bandyopadhyay and S. Bose,. "Synthesis and characterization of tricalcium phosphate with Zn and Mg based dopants,?," Journal of Materials Science ? Materials in Medicine, v.19 [7], 2008, p. 2669.
Y. Wu and S. Bose. "Nanocrystalline Hydroxyapatite: Micelle Templated Synthesis and Characterization," Langmuir, v.21, 2005, p. 3232.
Y. Wu, A. Bandyopadhyay, S. Bose. "Processing of Alumina and Zirconia Nano-powders and Compacts," Materials Science and Engineering A,, v.380 [1-, 2004, p. pp.349-55.
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