Award Abstract #0134548
CAREER: Integrated-Optic Nanoparticle Biosensor Arrays

NSF Org:	ECCS Division of Electrical, Communications and Cyber Systems
Initial Amendment Date:	February 6, 2002
Latest Amendment Date:	September 12, 2006
Award Number:	0134548
Award Instrument:	Standard Grant
Program Manager:	Rajinder P. Khosla ECCS Division of Electrical, Communications and Cyber Systems ENG Directorate for Engineering
Start Date:	February 15, 2002
Expires:	January 31, 2008 (Estimated)
Awarded Amount to Date:	$437400
Investigator(s):	Steven Blair blair@ece.utah.edu (Principal Investigator)
Sponsor:	University of Utah 75 S 2000 E SALT LAKE CITY, UT 84112 801/581-6903
NSF Program(s):	INT'L RES & EDU IN ENGINEERING, ELECT, PHOTONICS, & DEVICE TEC
Field Application(s):	0206000 Telecommunications
Program Reference Code(s):	OTHR, 9251, 9231, 1045, 101E, 0000
Program Element Code(s):	7641, 1517

ABSTRACT

Research world-wide on biosensing is motivated by numerous applications in environmental and food testing and clinical diagnostics, for example. However, the important problem of detecting in parallel a large number of molecular species from the very small samples typical of most collection procedures remains an elusive goal. This CAREER research plan focuses on solving this problem by merging the science of nanophotonics with waveguide biosensors and microfluidics for the development of a new class of molecular detection array.

The immobilization of metallic nanoparticles onto discrete zones of an optical waveguide surface makes the parallel detection of a large number of molecular species feasible. In each zone, capture molecules tethered to the nanoparticles preferentially bind to a particular molecular species through an affinity interaction. Strong localization of light about each nanoparticle allows for dramatic improvement in optical signal transduction, thereby facilitating the detection of small numbers of molecules bound within each zone.

Microfluidics will be used to deliver small sample volumes to each sensing zone and passive mixing structures will be studied in order to increase the molecular binding probability within each zone.

The education plan focuses on the creation of a summer optics workshop for secondary school physics and science teachers. As more demands are placed on teachers, and as technology continues to advance at a rapid pace, teachers need a way in which to further their knowledge of science and hands-on teaching methods. Detailed lesson plans and laboratory exercises will be developed for deployment in the classroom, with the goal of improving student understanding of and instruction in optics and the sciences, and encouraging students to pursue careers in engineering and science. Participation of teachers from Hispanic and Native American schools will be strongly encouraged.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

Davy Gérard, Jérôme Wenger, Nicolas Bonod, Evgeni Popov, Hervé Rigneault, Farhad Mahdavi, Steve Blair, José Dintinger and Thomas W. Ebbesen. "Nanoaperture-enhanced fluorescence: Towards higher detection rates with plasmonic metals," Physical Review B, v.77, 2008, p. 045413.

Farhad Mahdavi and Steve Blair. "Modeling Fluorescence Enhancement from Metallic Nanocavities," Plasmonics, v.2, 2007, p. 129.

J. Bishop, A. Chagovetz, and S. Blair. "Effects of fill fraction on the capture efficiency of nanoscale molecular transducers," Nanotechnology, v.17, 2006, p. 2442.

Y. Liu and S. Blair. "Fluorescence transmission through 1-D and 2-D periodic metal films," Optics Express, v.12, 2004, p. 3686.

Y. Liu, F. Mahdavi, and S. Blair. "Enhanced fluorescence transduction properties of metallic nanocavity arrays," IEEE Journal of Selected Topics in Quantum Electronics, v.11, 2005, p. 778.

Y. Liu, J. Bishop, L. Williams, S. Blair, and J. Herron. "Biosensing based upon molecular confinement in metallic nanocavity arrays," Nanotechnology, v.15, 2004, p. 1368.

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