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Award Abstract #0210223
NIRT: Enhancing the Properties of Nanoscale Electrospun Polymer Fibers thru Chemical Architecture, Surface Texturing Optimization Processing Protocols
| NSF Org: |
DMR
Division of Materials Research
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| Initial Amendment Date: |
July 29, 2002 |
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| Latest Amendment Date: |
July 29, 2002 |
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| Award Number: |
0210223 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Andrew J. Lovinger
DMR Division of Materials Research
MPS Directorate for Mathematical & Physical Sciences
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| Start Date: |
September 1, 2002 |
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| Expires: |
August 31, 2007 (Estimated) |
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| Awarded Amount to Date: |
$1087500 |
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| Investigator(s): |
John Rabolt rabolt@udel.edu (Principal Investigator)
Norman Wagner (Co-Principal Investigator)
Mary Galvin (Co-Principal Investigator)
Darrin Pochan (Co-Principal Investigator)
Kristi Kiick (Co-Principal Investigator)
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| Sponsor: |
University of Delaware
210 Hullihen Hall
Newark, DE 19716 302/831-2136
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| NSF Program(s): |
WESTERN EUROPE PROGRAM,
POLYMERS,
DMR SHORT TERM SUPPORT,
NANOSCALE: INTRDISCPL RESRCH T,
INTERFAC PROCESSES & THERMODYN
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| Field Application(s): |
0106000 Materials Research
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| Program Reference Code(s): |
AMPP, 9162, 9161, 5980, 5914, 1682, 1674
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| Program Element Code(s): |
5980, 1773, 1712, 1674, 1414
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ABSTRACT
This Nanoscale Interdisciplinary Team (NIRT), co-funded by the Divisions of Materials Research (DMR), Chemical and Transport Systems (CTS) and Design, Manufacturing and Industrial Innovation (DMII) will use genetically directed synthetic methods to permit exact control of the placement (at intervals of .6 nm, 1.0 nm, and/or 1.6 nm) of reactive chemical groups along a polypeptide backbone. These reactive groups will be both biologically active and electroactive providing novel materials for processing into fibers via electrospinning techniques. The fiber morphology, which will be varied by a judicious choice of processing conditions, will be characterized by electron microscopy, small angle neutron scattering and Raman spectroscopy. Mechanical properties of individual fibers will be evaluated using MEMS and NEMS devices while the biological activity of the electrospun fiber mats will be investigated by cell incubation studies.
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The results of these investigations will provide molecular design rules for future biomaterial constructs and will lead to a new generation of tissue scaffold materials for wound repair. The hybrid bio-electronic materials that result will address some of the lifetime and brightness issues for next generation flat panel computer displays that are critical for future industrial manufacturing. The integration of this research and education through externship experiences at DuPont and the development of new courses on nanomaterials design and processing will provide knowledge and an experience base that will equip students with the work-force ready skills critically needed by industry.
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PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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(Showing: 1 - 10 of 14)
(Showing: 1 - 14 of 14)
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, Danielle N. Rockwood, Kimberly A. Woodhouse, Joanna D. Fromstein, D. Bruce Chase, and John F. Rabolt. "Characterization of Biodegradable Polyurethane Microfibers for Tissue Engineered Scaffolds," J. Biomaterials Science, Polymer Edn., v.18, 2007, p. 743.
, Keun-Hyung Lee, Christopher M Snively, Steven Givens, D. Bruce Chase and John F. Rabolt. "Time-dependent Transformation of an Electrospun Isotactic Poly(1-butene) Fibrous Membrane," Macromolecules, v.40, 2007, p. 2590.
A. Bianco, C. Bertarelli, S. Frisk, J. F. Rabolt, M. Gallazzi and G. Zerbi. "Electrospun Poly(alkylthiophene)/Poly(ethylene oxide) fibers: Optical Characterization," Synthetic Metals, v.157, 2007, p. 276.
C. Casper, J. Stephens, N. Tassi, D. B. Chase and J. Rabolt. "Controlling Surface Morphology of Electrospun Polystyrene Fibers: Effect of Humidity and Molecular Weight in the Electrospinning Process," Macromolecules, v.37, 2004, p. 573.
C. Casper, N. Yamaguchi, K. Kiick, J. F. Rabolt. "Functionalizing Electrospun Fibers with Biologically Relevant Macromolecules," Biomacromolecules, v.6, 2005, p. 1998.
Cheryl Casper, William Yang, John F. Rabolt and Mary Farach-Carson. "Coating Electrospun Collagen and Gelatin Fibers with Perlecan Domain I for Increased Growth Factor Binding," Biomacromolecules, v.8, 2007, p. 1116.
Givens, S. R.; Gardner, K. H.; Rabolt, J. F.; Chase, D. B. "High-Temperature Electrospinning of Polyethylene Microfibers from Solution," Macromolecules, v.40, 2007, p. 608.
J. Stephens, D.B. Chase and J. F. Rabolt. "Raman Studies of Conformational Changes During Electrospinning in
Nylon 6 and Nylon 12," Macromolecules, v.37, 2004, p. 877.
J. Stephens, S. R. Fahnestock, R. S. Farmer, K. L. Kiick, D. B. Chase and J. Rabolt. "Effects of Electrospinning and Solution Casting Protocols on the Secondary Structure of Dragline Spider Silk Analog Investigated by FT-Raman Spectroscopy," Biomacromolecules, v.6, 2005, p. 1405.
K-H. Lee, Steve Givens, D. Bruce Chase and J. F. Rabolt. "Electrostatic Polymer Processing of Isotactic Poly(4-methyl-1-pentene) Fibrous Membrane," Polymer, v.47, 2006, p. 8013.
V. Daga, M.E. Helgeson, N.J. Wagner. "Electrospinning of Neat and Laponite-Filled Aqueous Poly(ethylene oxide) Solutions," JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, v.44, 2006, p. 1608.
V. Krikorian, D.J. Pochan. "Poly (L-lactic Acid)/Layered Silicate Nanocomposite: Fabrication, Characterization, and Properties," Chemistry of Materials, v.15, 2003, p. 4317.
V. Krikorian, D.J. Pochan. "Unusual Crystallization Behavior of Organoclay Reinforced Poly (L-Lactic Acid) Nanocomposites," Macromolecules, v.37, 2004, p. 6480.
V. Krikorian, D.J. Pochan. "Crystalliaztion Behavior of Poly (l-lactic acid) Nanocomposites: Nucleation and Growth Probed by Infrared Spetroscopy," Macromolecules, v.38, 2005, p. 6520.
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