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Award Abstract #0210238
NIRT: Ink Jetting of Nanostructured Matrices for Controlled Gene Delivery
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
September 11, 2002 |
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| Latest Amendment Date: |
March 5, 2004 |
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| Award Number: |
0210238 |
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| Award Instrument: |
Continuing grant |
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| Program Manager: |
Marc S. Ingber
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
September 15, 2002 |
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| Expires: |
August 31, 2007 (Estimated) |
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| Awarded Amount to Date: |
$1010000 |
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| Investigator(s): |
Prashant Kumta pkumta@engr.pitt.edu (Principal Investigator)
Lynn Walker (Co-Principal Investigator)
Lee Weiss (Co-Principal Investigator)
Phil Campbell (Co-Principal Investigator)
Jeffrey Hollinger (Co-Principal Investigator)
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| Sponsor: |
Carnegie-Mellon University
5000 Forbes Avenue
PITTSBURGH, PA 15213 412/268-8746
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| NSF Program(s): |
NANOSCALE: INTRDISCPL RESRCH T,
PARTICULATE &MULTIPHASE PROCES
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| Field Application(s): |
0308000 Industrial Technology
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| Program Reference Code(s): |
SMET, OTHR, 9231, 9178, 1788, 1674, 0000
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| Program Element Code(s): |
1674, 1415
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ABSTRACT
ABSTRACT
CTS-0210238
P. Kumta, L. Walker, L. Weiss, P. Campbell and J. Hollinger
Carnegie Mellon University
A novel techniques based on modification of ink jet printing technology for controlled Gene delivery and development of a new technology for tissue engineering is proposed. The PIs seek to create a biomimetic extracellular matrix with controlled temporal-spatial patterns of NanoCaPs that contains DNAs or plasmid growth factor. The controlled patterns will be created with the ink-jet technology and the performance will be evaluated in-vitro.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Daiwon Choi a, Prashant N. Kumta. "Mechano-chemical synthesis and characterization of nanostructured beta TCP powder," Materials Science and Engineering C, v.27, 2007, p. 377.
Dana Olton, Jinhua Li, Mary E. Wilson, Todd Rogers, John Close, Leaf Huang, Prashant N. Kumta, Charles Sfeir. "Nanostructured calcium phosphates (NanoCaPs) for non-viral gene," Biomaterials, v.28, 2007, p. 1267.
Hsu-Feng Ko b, Charles Sfeir c, Prashant N. Kumta. "In situ synthesis and characterization of porous polymer-ceramic composites as scaffolds for gene delivery," Materials Science and Engineering C, v.27, 2007, p. 479.
Il-Seok Kima,∗ , Prashant N. Kumta. "Sol?gel synthesis and characterization of nanostructured hydroxyapatite powder," Materials Science and Engineering B, v.111, 2004, p. 232.
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