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Award Abstract #0210298
NIRT: Nanoengineered shells for encapsulation and controlled release
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
August 13, 2002 |
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| Latest Amendment Date: |
May 30, 2003 |
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| Award Number: |
0210298 |
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| Award Instrument: |
Continuing grant |
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| Program Manager: |
Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
September 1, 2002 |
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| Expires: |
August 31, 2007 (Estimated) |
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| Awarded Amount to Date: |
$899042 |
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| Investigator(s): |
Yuri Lvov ylvov@latech.edu (Principal Investigator)
Michael Pishko (Co-Principal Investigator)
Michael McShane (Co-Principal Investigator)
Melgardt De Villiers (Co-Principal Investigator)
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| Sponsor: |
Louisiana Tech University
P O BOX 3168 TECH STATION
Ruston, LA 71272 318/257-5075
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| NSF Program(s): |
EXP PROG TO STIM COMP RES,
BIOMEDICAL ENGINEERING,
INTERFAC PROCESSES & THERMODYN
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| Field Application(s): |
0203000 Health
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| Program Reference Code(s): |
OTHR, 9150, 1674, 0000
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| Program Element Code(s): |
9150, 5345, 1414
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ABSTRACT
0210298
Lvov
This proposal was received in response to the Nanoscale Science and Engineering Initiative, NSF 01-157, category NIRT.
This project targets the synthesis of nanoscale functional materials and their potential for applications in medical and biological areas. The research team has been assembled to develop methods for fabrication of useful composite materials based on principles of self-assembly and includes researchers in chemistry, physics, engineering, biomaterials, and pharmacology. The nano-encapsulation method to be elaborated involves the formation of a colloidal core with defined composition and size, and the preparation of an outer shell providing the required stability, permeability, compatibility, release of core material, and catalytic or affinity properties.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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(Showing: 1 - 10 of 46)
(Showing: 1 - 46 of 46)
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A. Zahr, C. Davis, M. Pishko. "Phagocytosis of Core-Shell Nanoparticles modified at the surface of the polyelectrolyte nanoshell with Poly(ethylene glycol)," Langmuir, v.22, 2006.
A.s. Zahr, M. M. De Villiers, M.V. Pishko. "Encapsulation of drug nanoparticles in self-assembled macromolecular nanoshells," Langmuir, v.21, 2005, p. 403.
C. Karnati, H. Du, F. Ji, Y. Lvov, W. Chen, A. Mulchandani. "Organophosphorus Hydrolase Multilayer Modified Microcantilevers for Organophosphorus Detection," Biophysics Biochemistry, v.95, 2006, p. 333.
Chinnayelka, C., McShane, M.J.. "Microcapsule Biosensors using Competitive Binding RET Assays based on Apo-Enzymes," Analytical Chemistry, v.77, 2005, p. 5501.
D. Kommireddy, A. Patel, T. Shutava, D. Mills, Y. Lvov. "Layer-by-Layer Assembly of TiO2 Nanoparticle fro Stable Hydrophilic Biocompatible Coating," J. Nanoscience Nanotechnology, v.5, 2005, p. 1081.
D. Kommireddy, I. Ichinose, Y. Lvov, D. Mills. "Nanoparticle Multilayer: Surface Modification for Cell Attachment and Growth," J. Biomedical Nanotechnology, v.1, 2005, p. 286.
D. Kommireddy, S. Sriram, Y. Lvov, D. Mill. "Layer-by-Layer Assembled TiO2 Nanoparticle Thin Films - A New Surface Modification Approach for Stem Cell Attachment," Biomaterials, v.27, 2006, p. 4296.
D. Patel, R. Aithal, M. Tien, G. Krishna, Y Lvov, D. Kuila. "Nanoassembly of Manganese Peroxidase and Lignin Peroxidase for Biocatalysis in Aqueous and Nonaqueous Media," J. Colloids & Surfaces: B, v.43, 2005, p. 13.
D. Shchukin, A. Patel, G. Sukhorukov, Y. Lvov. "Nanoassembly of Biodegradable Microcapsules for DNA Encasing," J. American Chemical Society, v.126, 2004, p. 3374.
D. Shchukin, D. Kommireddy, T. Cui, G. Sukhorukov, Y. Lvov. "Fabrication of Polyelectrolyte/Protein Microarrays Using a Laminar Flow Microfluidic Device," Advanced Materials, v.16, 2004, p. 389.
D. Shchukin, D. Sviridov, Y. Lvov, G. Sukhorukov. "Photocatalytic Microreactors Based on TiO2-modified Polyelectrolyte Multilayer Capsules," Photochem. Photobiol. Science, v.2, 2003, p. 975.
D. Shchukin, R. Price, Y. Lvov. "Biomimetic Synthesis of Vaterite in the Interior of Clay Nanotubules," Small (Nano, Micro), v.1, 2005, p. 510.
D. Shchukin, T. Shutava, G. Sukhorukov, Y. Lvov. "Modified Polyelectrolyte Microcapsules as Smart Defense Systems," Chemistry of Materials, v.16, 2004, p. 3446.
F. Hua, T. Cui, Y. Lvov. "Ultrathin Cantilevers Based on Polymer-Ceramic Nanocomposite Assembled through Layer-by-Layer Adsorption," Nano Letters, v.4, 2004, p. 823.
G. Krishna, T. Shutava, Y. Lvov. "Lipid Modified Polyelectrolyte Microcapsules with Controlled Diffusion," Chemical Communications, 2005, p. 2796.
G. Krishna, Z. Lu, M. DeVilliers, Y. Lvov. "Composite Phospholipid - Calcium Carbonate Microparticles: Influence of Anionic Phospholipids on the Crystallization of Calcium Carbonate," J. Phys. Chemistry B, v.110, 2006, p. 247.
H. Ai, I. Ichinose, S. Jones, D. Mills, Y. Lvov, X. Qiao. "Biocompatible Nanofilm Assemblies on Silicone Rubber for Neuron," J. Neuroscience Methods, v.128, 2003, p. 1.
H. Ai, Y. Lvov, D. Mills, J. Alexander, S. Jones. "Coating and Selective Deposition of Nanofilm on Silicone Rubber for Cell Adhesion and Growth," Cell Biochemistry and Biophysics, v.38, 2003, p. 103.
H. Zhu, E. Stein, Z. Lu, Y. Lvov, M. McShane. "Synthesis of Monodisperse Manganese Carbonate Microparticles," Chemistry Materials, v.17, 2005, p. 2328.
K. Varahramyan, Y. Lvov. "Nanomanufacturing by Layer-by-Layer Assembly - From Nanoscale Coating to Device Applications," J. Nanotechnology and Nanoengineering, v.220, 2006, p. 29.
L. Pastorino, S. Disawal, Y. Lvov, V. Erokhin. "Complex Catalytic Colloids on the Basis of Firefly Luciferase as Optical Nanosensor Platform," Biotechnology and Bioengineering, v.84, 2003, p. 286.
M. Agarwal, Y. Lvov, K. Varahramyan. "Conductive Wood Microfibers for Smart Paper Through Layer-by-Layer Nanocoating," Nanotechnology, v.17, 2006, p. 5319.
M. Li, D. Mills, Y. Lvov, T. Cui, M. McShane. "Comparison of Selective Attachment and Growth of Smooth Muscle Cells on Gelatin- and Fibronectin-coated Micropatterns," J. Nanoscience Nanotechnology, v.5, 2005, p. 1809.
M. Song, M. De Villiers. "Effect of a change in crystal polymorph on the degree of adhesion between micronized drug particles and large homogenous carrier particles during an interactive mixing process," Pharmaceutical Development and Technology, v.9, 2004, p. 387.
M. Song, N. Li, S. Sun, M. De Villiers. "Effect of processing variables on the release and particulate properties of sustained release amoxicillin microcapsules prepared by emulsion solvent evaporation.," Die Pharmazie, v.60, 2005, p. 278.
M.M. De Villiers, C.M.Van Eeden, S.F. Malan, B. Devarakonda. "The relationship between surface adsorption and the hydrolysis of amitraz in anionic surfactant solutions.," J. of Environmental Science and Health, v.40, 2005, p. 215.
N. Li, D. Kommireddy, Y. Lvov, L. Tiedt, M. De Villiers. "Nanoparticle Multilayers: Surface modification of Photosensitive Drug Microparticles for Increased Stability and In Vitro Bioavailability," J. Nanoscience Nanotechnology, v.6, 2006, p. 3252.
N. Pargaonkar, Y. Lvov, N. Li, J. Steenekamp, M. de Villiers. "Controlled Release of Dexamethasone from Microcapsules Produced by Polyelectrolyte Layer-by-Layer Nanoassembly," Pharmaceutical Research, v.22, 2005, p. 826.
N. Veerabadran, R. Price, Y. Lvov. "Clay Nanotubules for Drug Encapsulation and Sustained Release," NANO, v.2, 2007, p. 215.
N. Veerabadran, S. Stewart, Y. Lvov, D. Mills. "Nanoencapsulation of Stem Cells within Polyelectrolyte Multilayer Shell," Macromolecular Bioscience, v.7, 2007, p. 476.
Q. Xing, S. Eadula, Y. Lvov, v. 8, 198, v. 8, 1987. "Cellulose Fiber - Enzyme Composites Through the Layer-by-Layer Nanoassembly," Biomacromolecules, v.8, 2007, p. 1987.
R. Ghan, T. Shutava, A. Patel, V. John, Y. Lvov. "Enzyme Catalyzed Polymerization of Phenols within Polyelectrolyte Microcapsules," Macromolecules, v.37, 2004, p. 4519.
R. Nohria, R. Killan, Yi Su, D. Kikshit, Y. Lvov, K. Varahramyan. "Humidity Sensor Based on Ultrathin Polyaniniline Film Deposited by Layer-by-Layer Nanoassembly," Sensors and Actuators B, v.114, 2006, p. 218.
T. Shutava, M. Prouty, V. Agabekov, Y. Lvov. "Antioxidant Properties of Layer-by-Layer Films on the Basis of Tannic Acid," Chem. Letters, v.35, 2006, p. 1144.
T. Shutava, D. Kommireddy, Y. Lvov. "Polyelectrolyte / Enzyme Multilayer As Functional Protective Nano/barrier in Oxidizing Media," J. American Chemical Society, v.128, 2006, p. 9926.
T. Shutava, M. Prouty, D. Kommireddy, Y. Lvov. "pH Responsible Decomposable Layer-by-Layer Films and Capsules on the Basis of Tannic Acid," Macromolecules, v.38, 2005, p. 2850.
T. Shutava, Y. Lvov. "Nanoengineered Microcapsules of Tannic Acid and Chitosan for Protein Encapsulation," J. Nanoscience Nanotechnology, v.6, 2006, p. 1655.
W. Liebenberg, E. Engelbrecht, A. Wessels, W. Yang, M. de Villiers. "A comparative study of the release of active ingredients from semi-solid cosmeceuticals measured with a Franz, Enhancer or flow-through cell diffusion apparatus," J. Food and Drug Analysis, v.12, 2004, p. 19.
W. Yang, M. De Villiers. "The solubilization of the poorly water-soluble drug nifedipine by water-soluble 4-sulphonic calix[n]arenes," J. of Pharmaceutics and Biopharmaceutics, v.58, 2004, p. 629.
W. Yang, M.M. de Villiers. "Aqueous solubilization of furosemide by supramolecular complexation with 4-sulphonic calix[n]arenes," J. Pharmacy and Pharmacology, v.56, 2004, p. 487.
Z. Lu, M. Prouty, C. Leuschner, Y. Lvov. "Layer-by-Layer Engineered Nanoparticles for Sustained Release of Phor21-âCG(ala) Anticancer Peptide," J. Biomedical Nanotechnology, v.3, 2007, p. 184.
Z. Lu, M. Prouty, Z. Guo, C. Kumar, Y. Lvov. "Magnetic Switch of Permeability for Polyelectrolyte Microcapsules Embedded with Co@Au Nanoparticles," Langmuir, v.21, 2005, p. 2042.
Z. Lu, T. Shutava, N. Sahiner, V John, Y. Lvov. "Photopolymerization of Acrylamide Derivatives in Polyelectrolyte Microcapsules," Chemical Letters, v.34, 2005, p. 1536.
Z. Zheng, J. McDonald, R. Khillan, T. Shutava, G. Grozdits, Y. Lvov. "Layer-by-Layer Nanocoating of Lignocellulose Fibers for Enhanced Paper properties," J. Nanoscience Nanotechnology, v.6, 2006, p. 624.
Z. Zheng, J. McDonald, R. Khillan, T. Shutava, G. Grozdits, Y. Lvov. "Layer-by-Layer Nanocoating of Lignocellulose Fibers for Enhanced Paper properties," J. Nanoscience Nanotechnology, v.6, 2006, p. 624.
Zhu, H., Srivastava, R., McShane, M.J.. "Spontaneous Loading of Positively-Charged Macromolecules into Alginate-Templated Polyelectrolyte Multilayer Capsules," Biomacromolecules, v.6, 2005, p. 2221.
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