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Award Abstract #0210580
NIRT: For Biomedical Nanotube Technology
| NSF Org: |
EEC
Division of Engineering Education and Centers
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| Initial Amendment Date: |
September 11, 2002 |
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| Latest Amendment Date: |
September 21, 2006 |
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| Award Number: |
0210580 |
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| Award Instrument: |
Continuing grant |
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| Program Manager: |
Lynn Preston
EEC Division of Engineering Education and Centers
ENG Directorate for Engineering
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| Start Date: |
September 15, 2002 |
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| Expires: |
August 31, 2007 (Estimated) |
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| Awarded Amount to Date: |
$1600000 |
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| Investigator(s): |
Charles Martin crmartin@chem.ufl.edu (Principal Investigator)
Jon Stewart (Co-Principal Investigator)
Rajiv Singh (Co-Principal Investigator)
Donn Dennis (Co-Principal Investigator)
Richard Rogers (Co-Principal Investigator)
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| Sponsor: |
University of Florida
1 UNIVERSITY OF FLORIDA
GAINESVILLE, FL 32611 352/392-3516
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| NSF Program(s): |
SOLID STATE & MATERIALS CHEMIS,
NANOSCALE: INTRDISCPL RESRCH T,
ENGINEERING RESEARCH CENTERS,
PARTICULATE &MULTIPHASE PROCES,
INTERFAC PROCESSES & THERMODYN,
CATALYSIS AND BIOCATALYSIS
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| Field Application(s): |
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| Program Reference Code(s): |
OTHR, AMPP, 9161, 7202, 1674, 1589, 0000
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| Program Element Code(s): |
1762, 1674, 1480, 1415, 1414, 1401
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ABSTRACT
This four-year Nanoscale Interdisciplinary Research Team (NIRT) project at the University of Florida with ProfessorCharles R. Martin as principal investigator, conducts a broad-based and systematic investigation of the development of smart nanotubes that are bioengineered and tailor-designed so as to accomplish specific biomedical/biochemical functions. Silica asn polymeric nanotubes will be extensively used in this research effort. Functionalized biodegradable and biocompatible poly( (lactide) nanotubes will be prepared. The objective of the research program include: (1) to show that the chemical microenvironment within biochemically-functionalized nanotubes can be fine-tuned so as promote specific desired biochemical processes; (2) to show that such nanotubes can be capped via self-assembly chemistry with nanoparticle caps; (3) to demonstrate that these nanoparticle caps can be attached via chemical bond that dissociate when a specific intercellular chemical signal is detected; (4) to show that such nanotubes can be tagged on their outer surfaces with antibodies that recognize specific cell types; and (5) to prove that all of these concepts can be used in concert to design new nanotube-based DNA transfection vechicles that deliver genetic material to specific desired cell types.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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(Showing: 1 - 10 of 23)
(Showing: 1 - 23 of 23)
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1. Hillebrenner, H.; Buyukserin, F.; Stewart, J.D.; Martin, C.R.. "Template Synthesized Nanotubes for Biomedical Delivery Applications," Nanomedicine, v.1, 2006, p. 39.
1. Martin, C. R.; Kohli, P.. "Emerging Field of Nanotube Technology," Nature Drug Discovery, v.2, 2003, p. 29.
2. Kohli, P.; Martin, C. R.. "Smart Nanotubes for Biotechnology," Drug News and Perspectives, v.16, 2003, p. 566.
Baker, L.A.; Choi, Y.; Martin, C.R. "Nanopore Membranes for Biomaterials Synthesis, Biosensors and Bioseparations," Curr. Nanosci., v.2, 2006, p. 243.
Buyukserin, F.; Kang, M.; Martin, C.R.. "Plasma-Etched Nanopore Polymer Films and their use as Templates to Prepare Nano Test Tubes," Small, v.3, 2007, p. 106.
Buyukserin, F.; Kohli, P.; Wirtz, M.O.; Martin, C.R.. "Electroactive Nanotubes Membranes and Redox-Gating," Small, v.3, 2007, p. 266.
Gasparac R, Mitchell DT, Martin CR. "Electropheretic DNA Transport through nanoporous membranes," ELECTROCHIM ACTA, v.49, 2004, p. 847.
Gasparac, R.; Kohli, P.; Mota, M. O.; Trofin, L.; Martin, C. R.. "Template Synthesis of Nano Test Tubes," Nano Letters, v.4, 2004, p. 513.
Harrell, C.C.; Kohli, P.; Siwy, Z.; Martin, C.R.. "DNA-Nanotube Artificial Ion Channels," J. Am. Chem. Soc, v.126, 2004, p. 15646.
Harrell, C.C.; Siwy, Z.; Martin, C.R.. "Conical Nanopore Membranes ? Controlling the Nanopore Shape," Small, v.2, 2006, p. 194.
Heins, E.A.; Baker, L.A.; Siwy, Z.S.; Mota, M.O.; Martin, C.R.. "The Effect of Crown Ether on Ion Currents through Synthetic Membranes Containing a Single Conically Shaped Nanopore," J. Phys. Chem., v.105, 2005, p. 18400.
Heins, E.A.; Siwy, Z.S.; Baker, L.A.; Martin, C.R.. "Detecting Single Porphyrin Molecules in a Conically Shaped Synthetic Nanopore," Nano Lett., v.5, 2005, p. 1825.
Hillebrenner, H.; Kang, M.; Buyukserin, F.; Motta, M.; Stewart, J.D.; Martin, C.R.. "Corking Nano Test Tubes by Chemical Self-Assembly," J. AM. CHem. Soc., v.128, 2006, p. 4236.
Hou, S.; Kohli, P.; Gasparac, R.; Martin, C. R.. "Layer-by-Layer Nanotube Template Synthesis," J. Am. Chem. Soc., v.126, 2004, p. 5674.
Hou, S.; Wang, J.; Martin, C.R.. "Template-Synthesized Protein Nanotubes," Nano Lett., v.5, 2005, p. 231.
Hou, S.; Wang, J.; Martin, C.R.. "Template-Synthesized DNA Nanotubes," J. Am. Chem. Soc., v.127, 2005, p. 8586.
Kang, M.; Yu, S.; Li, N.; Martin, C.R.. "Nanowell-Array Surfaces," Small, v.1, 2005, p. 69.
Kohli, P.; Martin, C. R.. "Smart Nanotubes for Biotechnology," Current Pharmaceutical Biotechnology, v.6, 2005, p. 35.
Kohli, P.; Wirtz, M.; Martin, C. R.. "Nanotubule Bio-nanosensors," Electroanalysis, v.16, 2004, p. 9.
Miller, S.A.; Martin, C.R.. "Redox Modulation of Electroosmotic Flow in a Carbon Nanotube Membrane," J. Am. Chem. Soc., v.126, 2004, p. 6226.
Sexton, L.T.; Horne, L.P.; Martin, C.R.. "Developing Synthetic Conical Nanopores for Biosensing Applications," Molecular BioSystems, v.3, 2007, p. 667.
Siwy, Z.; Heins, E.; Harrell, C.C.; Kohli, P.; Martin, C.R.. "Conical Nanotube Ion-Current Rectifiers ? The Role of Surface Charge," J. Am. Chem. Soc,, v.126, 2004, p. 10850.
Siwy, Z.; Troffin, L.; Kohli, P.; Baker, L.A.; Trautmann, C.; Martin, C.R.. "Protein Biosensors Based on Biofunctionalized Conical Gold Nanotubes," J. Am. Chem. Soc., v.127, 2005, p. 5000.
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