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Award Abstract #0218359
QuBIC: Molecular Robotics for DNA Nanostructures
| NSF Org: |
CCF
Division of Computer and Communication Foundations
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| Initial Amendment Date: |
July 23, 2002 |
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| Latest Amendment Date: |
July 23, 2002 |
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| Award Number: |
0218359 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Mitra Basu
CCF Division of Computer and Communication Foundations
CSE Directorate for Computer & Information Science & Engineering
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| Start Date: |
September 1, 2002 |
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| Expires: |
September 30, 2004 (Estimated) |
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| Awarded Amount to Date: |
$349995 |
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| Investigator(s): |
Hao Yan hao.yan@asu.edu (Principal Investigator)
John Reif (Co-Principal Investigator)
Daniel Kenan (Co-Principal Investigator)
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| Sponsor: |
Duke University
2200 W. Main St, Suite 710
Durham, NC 27705 919/684-3030
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| NSF Program(s): |
QuBIC
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| Field Application(s): |
0000099 Other Applications NEC
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| Program Reference Code(s): |
HPCC, 9218,
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| Program Element Code(s): |
1708
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ABSTRACT
EIA-0218359
Hao Yan
Duke University
Molecular Robotics for DNA Nanostructures
The objective of this project is to develop molecular motors that are incorporated into self-assembled DNA lattices. The main goal of this project will be to develop experimental proof-of concept demonstrations of the construction of novel DNA motors such as a DNA motor that is designed to have both translational and rotational motion. Incorporation of molecular motors into DNA arrays has many applications: It can selectively manipulate molecules using molecular motor devices arranged on DNA tiling arrays; A DNA array of motors may offer a mechanism to do DNA computation of arrays whose elements (the tiles) hold state; Parallel cellular automata computation may be executed from arrays of finite state automata each of which hold state. This project is also developing DNA nanostructures containing motors that operate autonomously without environmental changes. Methods are being tested to use "fuel DNA" to provide energy to drive the motion of DNA nanostructures. As an alternative approach, experiments are conducted to incorporate protein motors such as Kinesin into DNA lattices. In particular, the use of selective aptamer binding to link protein motors to periodic sites of a DNA lattice will be tested. The resulting arrays of protein motors have many applications to nanorobotics, e.g., they are potentially very useful for sorting and transport of nanoparticles.
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