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Award Abstract #0228143
SGER: Antibody-Conjugated Nanoparticle Films as Spectroscopic Sensors of Chemical Agents
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
August 28, 2002 |
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| Latest Amendment Date: |
August 28, 2002 |
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| Award Number: |
0228143 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Semahat S. Demir
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
September 1, 2002 |
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| Expires: |
August 31, 2004 (Estimated) |
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| Awarded Amount to Date: |
$100000 |
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| Investigator(s): |
Alexander Wei alexwei@purdue.edu (Principal Investigator)
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| Sponsor: |
Purdue University
Young Hall
West Lafayette, IN 47907 765/494-4600
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| NSF Program(s): |
BIOMEDICAL ENGINEERING
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| Field Application(s): |
0203000 Health
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| Program Reference Code(s): |
OTHR, 9237, 0000
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| Program Element Code(s): |
5345
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ABSTRACT
0228143
Wei
The proposed work will fabricate robust, antibody-conjugated gold nanoparticle films as substrates for surface-enhanced Raman scattering (SERS), a sensitive spectroscopic method with unmet potential for label-free chemical sensing. The SERS activities of the nanoparticle-based substrates will be optimized as a function of interparticle spacing and periodic order. Initial tests will be performed to recognize 2,4-dinitropohenol (DNP) in gas and aqueous environments and in the presence of several other aromatic compounds as a control for selectivity. The demonstration of substrates for selective chemical detection of DNP can be immediately parlayed into the development of Raman-based sensors of chemical warfare agents, including explosives, nerve gases, and mustard gases and vesicants.
The structure-activity relationships are based on theoretical considerations alone and have no experimental precedence. However, the proposed research is hypothesis-driven and addresses both short-term objectives for chemical sensor development and fundamental issues on the plasmonic properties of nanostructured metal films, with subsequent potential for applications beyond chemical and biological sensing.
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