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Award Abstract #0304521
NER: Design, Synthesis, and Evaluation of Novel Biologically-Inspired Nanostructured Materials as Bone Prostheses
| NSF Org: |
CMMI
Division of Civil, Mechanical, and Manufacturing Innovation
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| Initial Amendment Date: |
August 25, 2003 |
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| Latest Amendment Date: |
May 28, 2004 |
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| Award Number: |
0304521 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Ken Chong
CMMI Division of Civil, Mechanical, and Manufacturing Innovation
ENG Directorate for Engineering
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| Start Date: |
August 15, 2003 |
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| Expires: |
January 31, 2005 (Estimated) |
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| Awarded Amount to Date: |
$100000 |
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| Investigator(s): |
Thomas Webster Thomas_Webster@brown.edu (Principal Investigator)
Elliott Slamovich (Co-Principal Investigator)
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| Sponsor: |
Purdue University
Young Hall
West Lafayette, IN 47907 765/494-4600
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| NSF Program(s): |
BIOMEDICAL ENGINEERING,
MECHANICS OF MATERIALS
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| Field Application(s): |
0308000 Industrial Technology
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| Program Reference Code(s): |
AMPP, 9161, 1676
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| Program Element Code(s): |
5345, 1630
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ABSTRACT
Metallic alloys currently used as bone implants often fail due to poor bonding to juxtaposed bone (i.e. osseointegration). Osseointegration is necessary to stabilize the implant so that physiological loading conditions can be supported, thereby enabling the patient to lead a normal, active life. Incomplete osseointegration of implants can be caused by (i) surface properties that do not support new bone growth and (ii) mismatch of mechanical properties between an implant and surrounding bone that may lead to stress and strain imbalances that cause implant loosening, failure, and eventual surgical removal. The proposed study will design, synthesize, and evaluate biologically-inspired materials that mimic bone by incorporating dispersed nanoceramic particles in polymer matrices. Since all tissues of the body are nanostructured, positive results on the present study would provide evidence that the design of synthetic, biologically-inspired, nanomaterial formulations may increase the efficacy of implants in numerous applications.
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