Award Abstract #0323281
Biophotonics: Collaborative Research: In-vitro Diagnostics using a PBR Targeted Molecular Imaging Agent

NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Initial Amendment Date:	September 25, 2003
Latest Amendment Date:	August 18, 2008
Award Number:	0323281
Award Instrument:	Standard Grant
Program Manager:	Leon Esterowitz CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering
Start Date:	October 1, 2003
Expires:	September 30, 2009 (Estimated)
Awarded Amount to Date:	$311298
Investigator(s):	Darryl Bornhop darryl.bornhop@vanderbilt.edu (Principal Investigator)
Sponsor:	Vanderbilt University Division of Sponsored Research NASHVILLE, TN 37235 615/322-2631
NSF Program(s):	COLLABORATIVE RESEARCH, BIOPHOTONICS, IMAGING &SENSING
Field Application(s):	0000099 Other Applications NEC, 0203000 Health
Program Reference Code(s):	OTHR, 9251, 9231, 7234, 5979, 5953, 1606, 005E, 0000
Program Element Code(s):	V234, 7298, 7236

ABSTRACT

0323281

Bornhop

The overall objective of this research is to perform the fundamental studies of a novel optical reporter for further definition of its interaction with cells and their internal organelles. The multi-modal probes developed are lanthanide chelates and a peripheral benzodiazepine receptor (PBR) ligand. These molecules will be used in-vitro for the detection of specific pathological cells and to lend insights regarding mitochondria function and its relationship to disease.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

Bai, Mingfeng, Rone, Malena B., Papadopoulos, Vassilios and Bornhop, Darryl J.. "A Novel Functional Translocator Protein Ligand for Cancer Imaging," Bioconjugate Chemistry, v.18, 2007, p. 2018.

Bai, Mingfeng; Han, Zeqiu; Papadopoulos, Vassilios; Bornhop, Darryl. "A Novel Conjugable Translocator Protein Ligand Labeled with a Fluorescence Dye for in vitro Imaging," Bioconjugate Chemistry, 2007.

Bai, Mingfeng; Han, Zeqiu; Papadopoulos, Vassilios; Bornhop, Darryl. "A Novel Conjugable Translocator Protein Ligand Labeled with a Fluorescence Dye for in vitro imaging," Bioconjugate Chemistry, v.18, 2007, p. 1118.

H.C. Manning, J.M.M. Griffin, T.S. Goebel, M. A. Wegiel, R.C. Thompson, R.R. Price and D.J. Bornhop. "A PBR Targeted Molecular Imaging Agent for Cellular-Scale Bi-modal Imaging," Bioconjugate Chemistry, v.15, 2004, p. 1488.

Manning HC, Goebel T, Thompson RC, Price RR, Lee H, Bornhop DJ.. "Targeted Molecular Imaging Agents for Cellular-Scale Bi-modal Imaging," Bioconjugate Chemistry, v.15, 2004, p. 1488.

Manning, HC; Smith, SM; Sexton, M; Haviland, S; Bai, MF; Cederquist, K; Stella, N; Bornhop, DJ. "A peripheral benzodiazepine receptor targeted agent for in vitro imaging and screening," BIOCONJUGATE CHEMISTRY, v.17, 2006, p. 735-740. 

X. Wang, G. Ku, M.A. Wegiel, D.J. Bornhop, G. Stoica and L.V. Wang. "Non-invasive Photoacoustic Angiography of Animal Brains In Vivo with NIR Light and an Optical Contrast Agent," Optics Letters, v.29, 2004, p. 730.

X. Wang, G. Ku, M.A. Wegiel, D.J. Bornhop, G. Stoica and L.V. Wang. "Non-invasive Photoacoustic Angiography of Animal Brains In Vivo with NIR Light and an Optical Contrast Agent," Optics Letters, v.29, 2004, p. 730.

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