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Award Abstract #0326705
Collaborative Research: Origins and Spread of the Aspergillus-Gorgonian Coral Epizootic: Role of Climate and Environmental Facilitators
| NSF Org: |
OCE
Division of Ocean Sciences
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| Initial Amendment Date: |
September 10, 2003 |
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| Latest Amendment Date: |
April 27, 2007 |
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| Award Number: |
0326705 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Donald L. Rice
OCE Division of Ocean Sciences
GEO Directorate for Geosciences
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| Start Date: |
September 1, 2003 |
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| Expires: |
August 31, 2009 (Estimated) |
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| Awarded Amount to Date: |
$1162663 |
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| Investigator(s): |
C. Drew Harvell cdh5@cornell.edu (Principal Investigator)
Stephen Ellner (Co-Principal Investigator)
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| Sponsor: |
Cornell University - State
373 Pine Tree Road
Ithica, NY 14850 607/255-5014
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| NSF Program(s): |
BE-UF: ECOL OF INFECTIOUS DISE,
ECOLOGY OF INFECTIOUS DISEASES,
BE: NON-ANNOUNCEMENT RESEARCH
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| Field Application(s): |
0204000 Oceanography
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| Program Reference Code(s): |
SMET, OTHR, BIOT, 9251, 9183, 9178, 9169, 7242, 4444, 1670, 1355, 0000
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| Program Element Code(s): |
V361, 7308, 7242, 1629
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ABSTRACT
ABSTRACT
OCE-0326705 / OCE-0326983 / OCE-0326269 / OCE-0326698
Recent high rates of disease outbreaks on coral reefs may be caused by climate-related stress, increased inputs of new pathogens, or both. The inability to use traditional methods of disease management in marine systems (culling, vaccination, quarantine) adds urgency to understanding and controlling disease in the ocean. The most practical remediation for coral disease is to control inputs and spread. Yet, we do not know the origin of any coral pathogen nor do we understand mechanisms of transmission. The aspergillus - sea fan coral epizootic is an excellent model system for testing hypotheses about the origins of emergent marine disease, the relative importance of transmission and resistance in outbreaks and particularly the role of environmental facilitators. In this project, researchers at Cornell University, University of North Carolina at Chapel Hill, University of South Carolina, and the University of Maryland Biotechnology Institute will investigate this system through a research program combining linked experimental and theoretical approaches. The objectives are
(1) to determine the origins of the aspergillosis outbreak in sea fans, using microsatellite markers;
(2) to evaluate the role of host resistance through development of immunological assays;
(3) to evaluate experimentally the role of environmental facilitators in the outbreak;
(4) to assess demographic and spatial determinants of infection risk; and
(5) to develop a predictive theory of disease outbreak and spread through a spatial model for spread of disease in coral populations, embedded in an agent- based framework.
The project is expected to have broad educational and international impacts because will enrich undergraduate teaching programs in Akumal, Mexico, and train high school students, undergraduates, graduate students and postdoctoral fellows at field sites and at the home research institutions. The primary intellectual merit of this project is bringing current theory in wildlife disease to a tropical marine study system that is easily manipulated. The project will be enhanced by seeking applied outcomes for management of coral reefs and forging new directions in the ecology of marine and particularly coral reef diseases through interactions with NOAA and World Bank targeted research initiatives.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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(Showing: 1 - 34 of 34)
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Alker A, Kim K, Dube D, Harvell CD (2004). "Localized Induction of a Generalized Response Against Multiple Biotic Agents in Caribbean
Seafans.," Coral Reefs, v.23, 2004, p. 397.
Baker, DM, MacAvoy SE, Kim K. "Environmental Drivers of Coral Disease: The Relationship between Water Quality,??15N, and Aspergillosis of Caribbean Sea Fan Corals.," MEPS, 2007, p. 12.
Bruno J, Selig E, Casey K, Page C, Willis B, , Harvell, CD, Sweatman H, Melendy A. "Thermal stress and coral cover as drivers of coral disease," Pub Libr Science, 2007, p. 1220.
Bruno JF, Boyer KE, Duffy JE, Lee SE, Kertesz JS. "Effects of species identity and richness on primary production in benthic marine
communities.," Ecology Letters, v.8, 2005, p. 1165.
Bruno JF, O?Connor MI. "Cascading effects of predator diversity and omnivory in a marine food web.," Ecology Letters, v.8, 2005, p. 1048.
Bruno, Petes, Harvell and Hettinger.. "Nutrient enrichment can increase the severity of coral disease.," Ecology Letters, v.6, 2003, p. 1056.
Bush S, Precht W, Woodley JD, Bruno JF. "Indo-Pacific mushroom corals found on Jamaican reefs.," Coral Reefs, v.23, 2004, p. 234.
Cervino JM, K Winiarski-Cervino, SW Polson, T Goreau, GW Smith. "Identification of bacteria associated with a disease affecting the marine sponge Ianthella
basta, in New Britain, Papua, New Guinea.," MEPS, v.324, 2006, p. 139.
Couch CS, Mydlarz LD, Douglas NL. Harvell CD. "Variation in measures of immunocompetence of sea fan coral, Gorgonia ventalina, in the Florida Keys," Marine Biology, v.online, 2008.
Couch CS, Mydlarz LD, Harvell CD. "Spacial differences in immune response measures in sea fan corals of the Florida Keys," in preparation, 2007.
Douglas NL, Mullen K, Talmage S, Harvell CD. "Exploring the role of Chitinolytic Enzymes in the Sea Fan Coral Gorgonia ventalina.," Marine Biology, v.150, 2007, p. 1137.
Edmunds PJ, Bruno JF, Carlon DB. "Effects of depth and microhabitat on growth and survivorship of juvenile corals in the Florida
Keys," Marine Ecology Progress Series, v.278, 2004, p. 115.
Ellner SP and Rees M. "Integral projection models for species with complex demography.," American Naturalist, v.167, 2006, p. 410.
Ellner SP and Rees M. "Stochastic stable population growth in integral projection models.," Journal of Mathematical Biology, 2007, p. 410.
Gil-Aguedlo DL, Ali-Hassan L, Kim K, Smith GW. "Characterization of coral surface microbiota using metabolic profiling.," Proc. 10th Internat Coral Reef Symp, 2006, p. 146.
Gil-Aguedlo DL, C Myers, GW Smith, K Kim. "Changes in the microbial communities associated with Gorgonia ventalina during
Aspergillosis infection.," Diseases of Aquatic Organisms, v.69, 2006, p. 89.
Harvell CD, Aronson R, Baron N, Connell J, Dobson A, Ellner S, Gerber L, Kim K, Kuris A, McCallum H, Lafferty K, McKay B, Porter J, Pascual M, Smith G, Sutherland K, Ward J. "The Rising Tide of Ocean Diseases: Unsolved Problems and Research Priorities.," Frontiers in Ecology, v.23, 2004, p. 375.
Harvell CD, Jordan-Dahlgren E, Merkel S, Rosenberg E, Raymundo L, Smith G, Weil E, Willis B. "Coral Disease, Environmental Drivers and the Balance Between Coral and Microbial Associates.," Oceanography., v.20, 2007, p. 58.
Harvell et al.. "The Rising Tide of Ocean Disease," Frontiers in Ecology and Environment, v.2, 2004, p. 375.
Kim KA, Dobson F, Gulland MD, Harvell CD. "Diseases and the conservation of marine biodiversity. In Marine Conservation Biology, Norse
E and L Crowder [eds.]. Island Press.," Diseases and the conservation of marine biodiversity., v.-, 2005, p. -.
Kirk NL, Ward JR, Coffroth MA. "Stable Symbiodinium composition in the seafan Gorgonia ventalina during temperature and
disease stress.," Biol Bull, v.209, 2005, p. 227.
McCallum H, Kuris A, Harvell CD, Lafferty K, Smith G, Porter J. "Does Terrestrial Epidemiology Apply to Marine Systems?," Trends in Ecology and Evolution, v.19, 2004, p. 585.
Mullen , K., Harvell, C. D., and E. Peters.. "Coral Resistance to Disease," Coral Health and Disease, v.-, 2004, p. -.
Mydlarz L, Jones L, and Harvell CD. "Ecological Immunity of Invertebrates.," Ann. Rev. Ecology, Evolution, Systematics, v.37, 2006, p. 251.
Mydlarz LD and Harvell CD. "Peroxidase Activity and Inducibility in the Sea Fan Coral Exposed to a Fungal Pathogen.," Biochem Physiol, Part A. Mol Int Physiol., 2007, p. 5.
Mydlarz LD and Harvell CD. "Peroxidase Activity and Inducibility in the Sea Fan Coral Exposed to a Fungal Pathogen.," Biochem Physiol, Part A. Mol Int Physiol., v.146, 2007, p. 5.
Mydlarz LD, Harvell CD, Holthouse S, Peters E. "Cellular responses in sea fan corals: granular amoebocytes react to pathogen and climate stressors," PLoS One, v.3(3), 2008, p. 1811.
Precht WF, Miller SL, Aronson RB, Bruno JF, Kaufman L. "Reassessing U.S. coral reefs.," Science, v.308, 2005, p. 1741.
Rypien KL, Andras JP. "Isolation and characterization of microsatellite loci in Aspergillus sydowii, a pathogen of Caribbean sea fan corals," Molecular Ecology Notes, v.8, 2007, p. 230.
Ward JR, Kim K and Harvell CD. "Temperature affects coral disease resistance and pathogen growth.," MEPS, v.329, 2007, p. 115.
Ward JR, Rypien K, Bruno J, Harvell CD, Jordan E., Mullen K, Rodriguez-Martinez R, Sanchez J and Smith G. "Coral Diversity and Disease in Mexico.," Diseases of Aquatic Organisms, v.69, 2006, p. 23.
Ward, J. and Lafferty.. "The Elusive Baseline for Marine Disease," PloS, v.2, 2004, p. 0542.
Warren M, Leverette CL, Smith MA, Smith GW. "Determination of carotenoid as the purple pigment in Gorgonia ventalina sclerites using Raman microscopy," Spectrochim Acta A Mol Biomol Spectrosc, v.69, 2008, p. 1058.
Weil E, GW Smith, D Gil-Agudelo. "Status and progress in coral reef disease research.," Diseases of Aquatic Organisms., v.69, 2006, p. 1.
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