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Award Abstract #0327052
EID: Plague As a Model for Low Prevalence/epizootic Disease Dynamics
| NSF Org: |
EF
Emerging Frontiers
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| Initial Amendment Date: |
September 9, 2003 |
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| Latest Amendment Date: |
April 11, 2007 |
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| Award Number: |
0327052 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Samuel M. Scheiner
EF Emerging Frontiers
BIO Directorate for Biological Sciences
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| Start Date: |
September 1, 2003 |
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| Expires: |
August 31, 2009 (Estimated) |
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| Awarded Amount to Date: |
$1281000 |
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| Investigator(s): |
Michael Antolin michael.antolin@colostate.edu (Principal Investigator)
Paul Stapp (Co-Principal Investigator)
Colleen Webb (Co-Principal Investigator)
Ken Gage (Co-Principal Investigator)
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| Sponsor: |
Colorado State University
601 S Howes St
Fort Collins, CO 80523 970/491-6355
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| NSF Program(s): |
ECOLOGY OF INFECTIOUS DISEASES,
BE: NON-ANNOUNCEMENT RESEARCH
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| Field Application(s): |
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| Program Reference Code(s): |
SMET, EGCH, 9251, 9183, 9178, 9169, 9109, 7242
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| Program Element Code(s): |
V361, 7242, 1629
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ABSTRACT
Outbreaks of infectious diseases in natural populations of plants and animals arise when variation in climate influences density of hosts, contact and disease transmission between hosts, and the size of insect populations that transmit disease. Within these broad patterns, how a disease changes from outbreak conditions to low-level persistence is unknown. Plague, a disease of rodents caused by the bacterium Yersinia pestis, provides an ideal opportunity for studying disease outbreaks interspersed within lulls when disease is almost undetectable. After its introduction into North America, plague has affected most rodent species west of the Great Plains. Black-tailed prairie dogs, burrowing rodents living in social colonies on grasslands, suffer high mortality during outbreaks. Long-term studies in Colorado show that plague outbreaks are more common during El Nino years. This project aims to determine whether plague persists in reservoir hosts (other rodents), remains at low levels within prairie dogs or their fleas, or only moves into grasslands from other habitats following weather-related increases in densities of other rodents. Routes of infection will be studied by trapping rodents and fleas, combined with genetic fingerprinting to identify plague foci. These data will provide values for models that explore disease persistence and transmission.
Plague continues to be a human health concern; up to 3,000 worldwide cases are reported yearly. This research provides key information for minimizing disease incidence in the expanding populations of the western US. It is also part of long-term plague surveillance through the Shortgrass Steppe Long-Term Ecological Research project. Students from an urban, ethnically diverse undergraduate institution (Cal-State Fullerton) will gain unique experiences in field ecology, which increases the likelihood they will pursue careers in science.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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Antolin, M.F.. "Unpacking β: Within-host dynamics and evolutionary ecology of pathogen transmission.," Annu. Rev. Ecol. Evol. Systemat., v.39, 2008, p. 415.
Antolin, M.F., L.T. Savage, and R.J. Eisen.. "Landscape features influence genetic structure of black-tailed prairie dogs (Cynomys ludovicianus).," Landscape Ecology, v.21, 2006, p. 867.
Avashia, SB, Petersen JM, Lindley C, Schriefer ME, Gage KL, Cetron M, Thomas A. Demarcus TA, Kim DK, Buck J, Monteneiri JA, Lowell JL, Antolin MF, Kosoy MY, Carter LG, Chu MC, Hendricks K, David T. Dennis DL, and Kool JL.. "First reported prairie dog-to-human tularemia transmission, Texas, 2002," Emerging Infectious Diseases, v.10, 2004, p. 483.
Buzby. M., D. Neckels, M.F. Antolin, and D. Estep.. "Analysis of the sensitivity properties of a vector-borne model of plague.," Proc. Roy. Soc. Lond. Interface, v.5, 2008, p. 1099.
D.J. SALKELD and P. STAPP. "Seroprevalence Rates and Transmission of Plague
(Yersinia pestis) in Mammalian Carnivores," VECTOR-BORNE AND ZOONOTIC DISEASES, v.6, 2006, p. 231.
Eisen, R.J., S.W. Bearden, A.P. Wilder, J.A. Montenieri, M.F. Antolin, and K.L. Gage.. "Early-phase transmission of Yersinia pestis by unblocked fleas as a mechanism explaining rapidly spreading plague epizootics.," Proc. Nat. Acad. Sci. USA, v.103, 2006, p. 15380.
Lowell, J.L., D.M. Wagner, B. Atshabar, M. Antolin, A.J. Vogler, P. Keim, M.C. Chu, and K. L. Gage.. "Identifying sources of human exposure to plague.," Journal of Clinical Microbiology, v.43, 2005, p. 650.
Magle, S.B., B.T. McClintock, D.W. Tripp, G.C. White, M.F. Antolin, K.R. Crooks.. "Mark-resight methodology for estimating population densities for prairie dogs," Journal of Wildlife Management., 2007, p. 2.
Magle, S.B., B.T. McClintock, D.W. Tripp, G.C. White, M.F. Antolin, K.R. Crooks.. "A new method for estimating population densities for prairie dogs," Journal of Wildlife Management., v.71, 2007, p. 2067.
Salkeld, D. J., & P. Stapp.. "No evidence of deer mouse involvement in plague (Yersinia pestis) epizootics of prairie dogs.," Vector Borne and Zoonotic Diseases, v.8, 2008, p. 331.
Salkeld, D. J., & P. Stapp.. "Prevalence and abundance of fleas in black-tailed prairie dog burrows: implications for the transmission of plague (Yersinia pestis).," Journal of Parasitology, v.94, 2008, p. 616.
Salkeld, D.J., R.J. Eisen, M.F. Antolin, P.T. Stapp, and L. Eisen.. "Host usage and seasonal activity patterns of Ixodes kingi and I. sculptus (Acari: Ixodidae) in a Colorado prairie landscape, with a summary of published North American host records.," J. Vector Ecol., v.31, 2006, p. 168.
Salkeld, D.J., R.J. Eisen, P. Stapp, A.P. Wilder, J. Lowell, D.W. Tripp, D. Albertson, M.F. Antolin.. "The potential role of swift foxes (Vulpes velox) and their fleas in prairie-dop plague (Yersinia pestis) outbreaks," Journal of Wildlife Diseases, v.43, 2007, p. 425.
Stapp, P.. "Rodent communities in active and inactive colonies of black-tailed prairie dogs in shortgrass steppe.," Journal of Mammalogy,, v.88, 2007, p. 241.
Stapp, P.. "Trophic cascades and disease ecology.," Ecohealth, 2007, p. 121.
Stapp, P.. "Trophic cascades and disease ecology.," Ecohealth, v.4, 2007, p. 121.
Stapp, P., D. J. Salkeld, R. J. Eisen, R. Pappert, J. Young, L. G. Carter, K. L. Gage, D. W. Tripp & M. F. Antolin.. "Exposure of small rodents to plague during black-tailed prairie dog epizootics.," Journal of Wildlife Diseases, v.44, 2008, p. 724.
Stapp, P., M.F. Antolin, and M. Ball.. "Patterns of extinction in prairie dog metapopulations: plague outbreaks follow El Ni?o events," Frontiers in Ecology and the Environment, v.2, 2004, p. 235.
Webb, C.T., C.P. Brooks, K.L. Gage, and M.F. Antolin.. "Classic flea-borne transmission does not drive plague epizootics in prairie dogs.," Proc. Nat. Acad. Sci. U.S.A., v.103, 2006, p. 6236.
Wilder, A.P., E.J. Eisen, S. Bearden, J. Montenieri, M.F. Antolin, K.L. Gage.. "Oropsylla hirsuta (Siphonaptera: Ceratophyllidae) can support plague epizootics in black-tailed prairie dogs (Cynomys ludovicianus) by early-phase transmission of Yersinia pestis.," Vector-Borne and Zoonotic Diseases, v.8, 2008, p. 359.
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