Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
Start Date:
September 15, 2004
Expires:
January 31, 2009 (Estimated)
Awarded Amount to Date:
$287199
Investigator(s):
David Nolte nolte@physics.purdue.edu (Principal Investigator)
John Turek (Co-Principal Investigator)
Sponsor:
Purdue University
Young Hall
West Lafayette, IN 47907 765/494-4600
NSF Program(s):
BIOMEDICAL ENGINEERING, RESEARCH TO AID THE DISABLED
Field Application(s):
0203000 Health
Program Reference Code(s):
OTHR, 5345, 0000
Program Element Code(s):
5345, 5342
ABSTRACT
0401858
Nolte
A full-frame coherence imaging technique is proposed that uses a holographic coherence gate and CCD camera. The coherence gate is a transient grating formed by interference between the appropriately delayed reference beam and the image-bearing light from the sample. Preliminary work shows imaging of tumor masses with this technique. The group has been using custom in-house photorefractive films for the coherence gate, and proposes use of outside vendors for improved film properties. OCI has several attributes that distinguish it from OCT and make it an attractive alternative imaging technique. The PI has pioneered this new technology. This proposal will extend that early work, introducing improvements in dynamic range and speed that will allow a shift of research thrust to the imaging aspects of the technology.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Jeong, K; Turek, JJ; Nolte, DD. "Fourier-domain digital holographic optical coherence imaging of living tissue," APPLIED OPTICS, v.46, 2007, p. 4999-5008.
K.Jeong, L. Peng, J. J. Turek, M. R. Melloch and D. D. Nolte. "Fourier-domain Holographic Optical Coherence Imaging of Tumor Spheroids and Mouse Eye," Applied Optics, v.44, 2005, p. 1798.
Kwan Jeong, J. J. Turek and D. D. Nolte. "Functional Optical Coherence Imaging of Tumor Response to a Metabolic Electron Transport Inhibitor," Proceedings of the SPIE Photonics West Conference, vol. 6079, V. Tuchin, J. Izatt and J. Fujimoto, eds., San Jose Ca, Jan. 22-27 (2006), v.6079, 2006, p. 1.
Kwan Jeong, John J. Turek & David D. Nolte. "Imaging Motility Contrast in Digital Holography of Tissue Response to Cytoskeletal Anti-cancer Drugs," Optics Express, v.15, 2007, p. 14057.
Kwan Jeong, John J. Turek and David D. Nolte. "Phase-Contrast Optical Coherence Imaging of Tissue," Proceedings of SPIE - The International Society for Optical Engineering, Progress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, v.5690, 2005, p. 1.
Kwan Jeong, John J. Turek and David D. Nolte. "Biomedical Functional Imaging of Tissue in Coherence-Domain Speckle Holography," Photorefractive Effects and Materials, Proceedings of the Tenth International Conference, Guongan Zhang, Jungjin Xu, David Nolte and Detlef Kip, Eds., Trends in Optics and Photonics Series,, v.99, 2005, p. 1.
Kwan Jeong, John J. Turek, David D. Nolte. "Functional imaging by dynamic speckle in digital holographic optical coherence imaging," Proc. SPIE Vol. 6429, 64291V, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI; James G. Fujimoto, Joseph A. Izatt, Valery V. Tuchin; Eds., 2007.
Kwan Jeong, John J. Turek, Michael R. Melloch, David D. Nolte. "Functional Imaging in Photorefractive Tissue Speckle Holography," Opt. Commun., v.281, 2007, p. 1860.
P. Yu, M. Mustata, L. Peng, J. J. Turek, M. R. Melloch, P. M. W. French and D. D. Nolte. "Holographic Optical Coherence Imaging of Rat Osteogenic Sarcoma Tumor Spheroids," Applied Optics, v.43, 2004, p. 4862.
CONFERENCE PROCEEDINGS PRODUCED AS A RESULT OF THIS RESEARCH
Jeong, K; Peng, LL; Turek, JJ; Melloch, MR; Nolte, DD. "Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye," in Biomedical Topical Meeting., v.44, 2005, p. 1798-1805.
Jeong, K; Turek, JJ; Nolte, DD. "Phase-contrast optical coherence imaging of tissue," in Conference on Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX., v.5690, 2005, p. 412-421.
Jeong, K; Turek, JJ; Nolte, DD. "Digital holographic Optical Coherence Imaging of tumor tissue - art. no. 60791G," in Conference on Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X., v.6079, 2006, p. G791-G791.
Jeong, K; Turek, JJ; Nolte, DD. "Functional imaging by dynamic speckle in digital holographic optical coherence imaging - art. no. 64291V," in Conference Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI., v.6429, 2007, p. V4291-V4291.
Jeong, K; Turek, JJ; Nolte, DD. "Functional optical coherence Imaging of tumor response to a metabolic electron transport inhibitor - art. no. 60790K," in Conference on Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X., v.6079, 2006, p. K790-K790.
Nolte, DD; Jeong, K; Yu, P; Turek, JJ. "The physical basis of holographic optical coherence imaging of living tissue," in Conference on Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII., v.5316, 2004, p. 278-284.
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