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Award Abstract #0522668
Biophotonics: Microsphere Whispering Gallery Mode Biosensor
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
June 7, 2005 |
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| Latest Amendment Date: |
May 16, 2008 |
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| Award Number: |
0522668 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
September 1, 2005 |
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| Expires: |
August 31, 2009 (Estimated) |
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| Awarded Amount to Date: |
$459248 |
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| Investigator(s): |
Stephen Arnold arnold@poly.edu (Principal Investigator)
Iwao Teraoka (Co-Principal Investigator)
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| Sponsor: |
Polytechnic University of New York
Six Metrotech Center
Brooklyn, NY 11201 718/260-3550
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| NSF Program(s): |
BIOPHOTONICS, IMAGING &SENSING
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| Field Application(s): |
0000099 Other Applications NEC
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| Program Reference Code(s): |
OTHR, 0000
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| Program Element Code(s): |
7236
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ABSTRACT
Arnold
0522668
The objective of this proposal is to continue development of whispering gallery mode sensors. This objective will be pursued by advancing the sensor instrumentation through inclusion of polarization sensitivity and control and improving the testbed by using microfluidic techniques. The improvements will be validated by assessing the ability to detect single viruses using the WGM sensor. Finally, a theory component is proposed to improve understanding of the mechanisms involved.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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(Showing: 1 - 10 of 13)
(Showing: 1 - 13 of 13)
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I. Teraoka and S. Arnold. "Coupled whispering gallery modes in a multilayer-coated microsphere," Opt. Lett., v.32, 2007, p. 1147.
I. Teraoka and S. Arnold. "Whispering gallery modes in a microsphere coated with a high-refractive index layer:
Polarization-dependent sensitivity enhancement of the resonance-shift sensor and TE-TM
resonance matching," J. Opt. Soc. Amer. B, v.24, 2007, p. 653.
Keng, D., McAnanama, S. R., Teraoka, I. & Arnold, S.. "Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion.," Applied Physics Letters, v.91, 2007, p. 103902.
M. Noto, D. Keng, I. Teraoka, and S. Arnold. "Detection of protein orientation on silica surface using TE/TM whispering gallery modes," Biophysical Journal, v.92, 2007, p. 4466.
Noto, M., Khoshsima, M., Keng, D.,Teraoka, I., Kolchenko, V., & Arnold, S.. "Molecular weight dependence of a whispering gallery mode biosensor.," Applied Physics Letters, v.87, 2005, p. 223901.
O. Gaathon, J. Culic-Viskota, M. Mihnev, I. Teraoka and S. Arnold. "Enhancing sensitivity of a whispering gallery mode bio-sensor by sub-wavelength
confinement," Appl. Phys. Lett., v.89, 2006, p. 223901.
Ren, H. C., Vollmer, F., Arnold, S. & Libchaber, A.. "High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria.," Optics Express, v.15, 2007, p. 17410.
S. Arnold, R. Ramjit, D. Keng, V. Kolchenko and I. Teraoka. "MicroParticle PhotoPhysics Illuminates Viral Bio-sensing," J. Chem. Soc. Faraday Trans., v.137, 2008, p. 65.
Teraoka, I. & Arnold, S.. "Dielectric property of particles at interface in random sequential adsorption and its application to whispering gallery mode resonance-shift sensors.," Journal of Applied Physics, v.101, 2007, p. 023505.
Teraoka, I. & Arnold, S.. "Estimation of surface density of molecules adsorbed on a whispering gallery mode resonator: Utility of isotropic polarizability.," Journal of Applied Physics, v.102, 2007, p. 076109.
Teraoka, I. & Arnold, S.. "Variational principle in whispering gallery mode sensor responses.," Journal of the Optical Society of America B-Optical Physics, v.25, 2008, p. 1038.
Teraoka, I. & Arnold, S.. "Theory of resonance shifts in TE and TM whispering gallery modes by nonradial perturbations for sensing applications.," Journal of the Optical Society of America B-Optical Physics, v.23, 2006, p. 1381.
Vollmer, F. & Arnold, S.. "Whispering-gallery-mode biosensing: label-free detection down to single molecules.," Nature Methods, v.5, 2008, p. 591.
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