Award Abstract #0547657 CAREER: Proposal for Developing Enhanced Optical Coherence Tomography Systems And Optofluidic Systems for Biomedical Applications.
Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
Start Date:
February 1, 2006
Expires:
January 31, 2010 (Estimated)
Awarded Amount to Date:
$320002
Investigator(s):
Changhuei Yang chyang@caltech.edu (Principal Investigator)
Sponsor:
California Institute of Technology
1200 E California Blvd
PASADENA, CA 91125 626/395-6219
NSF Program(s):
BIOPHOTONICS, IMAGING &SENSING
Field Application(s):
0000099 Other Applications NEC
Program Reference Code(s):
OTHR, 1187, 1045, 005E, 0000
Program Element Code(s):
7236
ABSTRACT
0547657
Yang
The over-arching objective of the proposed research and educational plan is further utilization of the expertise that the PI has in the area of optical imaging in order to develop better modalities of imaging using contrast agents with OCT, develop a miniaturized, forward looking OCT probe, seek wider application for OCT among biological and biomedical fields and develop a miniature optical microscope that uses microfluidics to move imaged object over an imaging platform. The educational objectives have a focus on development of the student's mind as a whole, by inclusion of intuitive understanding as well as encouragement towards other endeavors such as artistic expression.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
2. Xiquan Cui, Lap Man Lee, Xin Heng, Weiwei Zhong, Paul W. Sternberg, Demetri Psaltis and Changhuei Yang. "Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging," Proceedings of the National Academies of Science, v.105, 2008, p. 10670.
Cui, XQ; Heng, X; Wu, JG; Yaqoob, Z; Scherer, A; Psaltis, D; Yang, CH. "Slanted hole array beam profiler (SHArP)- a high-resolution portable beam profiler based on a linear aperture array," OPTICS LETTERS, v.31, 2006, p. 3161-3163.
Demetri Psaltis, Steven Quake, and Changhuei Yang. "Developing optofluidic technology through the fusion of microfluidics and optics," Nature, v.442, 2006, p. 381.
Heng, X; Cui, XQ; Knapp, DW; Wu, JG; Yaqoob, Z; McDowell, EJ; Psaltis, D; Yang, CH. "Characterization of light collection through a subwavelength aperture from a point source," OPTICS EXPRESS, v.14, 2006, p. 10410-10425.
Heng, X; Hsiao, E; Psaltis, D; Yang, CH. "A high resolution optofluidic microscope with optical tweezer actuation - art. no. 644113," IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES V, v.6441, 2007, p. 44113-44113.
Jian Ren, Jigang Wu, Emily J. McDowell, and Changhuei Yang. "Manual-scanning optical coherence tomography probe based on position tracking," Optics Letters, v.34, 2009, p. 3400.
Jigang Wu, Xiquan Cui, Lap Man Lee & Changhuei Yang. "The application of Fresnel zone plate based projection in optofluidic microscopy," Optics Express, v.16, 2008, p. 15595.
Lap Man Lee, Xiquan Cui and Changhuei Yang. "The Application of on-chip Optofluidic Microscopy for Imaging Giardia lamblia Trophozoites and Cysts," Biomedical Microdevices, v.11, 2009, p. 951.
McDowell, EJ; Cui, XQ; Yaqoob, Z; Yang, CH. "A generalized noise variance analysis model and its application to the characterization of 1/f noise," OPTICS EXPRESS, v.15, 2007, p. 3833-3848.
Wu, JG; Yaqoob, Z; Heng, X; Lee, LM; Cui, XQ; Yang, CH. "Full field phase imaging using a harmonically matched diffraction grating pair based homodyne quadrature interferometer," APPLIED PHYSICS LETTERS, v.90, 2007.
Xin Heng, David Erickson, Larry R. Baugh, Zahid Yaqoob, Paul W. Sternberg, Demetri Psaltis, and Changhuei Yang.. "Optofluidic microscopy: A Method for Implementing High Resolution Optical Microscope On A Chip," Lab on a Chip, v.6, 2006, p. 1274.
