Award Abstract #0548673
Biophotonics: In-Vivo Femtosecond Laser Micro-Surgery Combined with Two-Photon Imaging using Optical MEMS Components

NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Initial Amendment Date:	September 27, 2005
Latest Amendment Date:	September 27, 2005
Award Number:	0548673
Award Instrument:	Standard Grant
Program Manager:	Leon Esterowitz CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering
Start Date:	May 1, 2005
Expires:	August 31, 2008 (Estimated)
Awarded Amount to Date:	$512825
Investigator(s):	Adela Ben-Yakar ben-yakar@mail.utexas.edu (Principal Investigator)
Sponsor:	University of Texas at Austin P.O Box 7726 Austin, TX 78713 512/471-6424
NSF Program(s):	BIOPHOTONICS, IMAGING &SENSING, BIOMEDICAL ENGINEERING, RESEARCH TO AID THE DISABLED
Field Application(s):
Program Reference Code(s):	OTHR, 7236, 0000
Program Element Code(s):	7236, 5345, 5342

ABSTRACT

0423732

Solgaard

This proposal describes a research program that will explore the frontiers of novel photonics and nanotechnology methods to develop a new class of miniaturized probes for biomedical imaging and microsurgery in-vivo. The objectives of this proposal are (1) to study the fundamentals of femtosecond laser microsurgery performed deep in tissue, (2) to explore the delivery of femtosecond laser pulses with pulse energies up to 1-uJ using a new class of airguiding photonic band-gap fibers, (3) to develop miniature scanners based on Micro-Electro-Mechanical Systems (MEMS) technology, (4) to develop MEMS based spectral phase modulator in combination with a passive thin film coating technique to compensate for pulse broadening, and (5) to integrate these components into a macroscopic microsurgery system and evaluate their performance in-vitro.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

Christopher Hoy, Nicholas Durr, Pengyuan Chen, Wibool Piyawattanametha, Hyejun Ra, Olav Solgaard, and Adela Ben-Yakar. "Miniaturized probe for femtosecond laser microsurgery and two-photon imaging," Optics Express, v.16, 2008, p. 9996.

Frederic Bourgeois and Adela Ben-Yakar. "Femtosecond laser nanoaxotomy properties and their effect on axonal recovery in C. elegans," Optics Express, v.15, 2007, p. 8521.

Nicholas J. Durr, Timothy Larson, Danielle K. Smith, Brian A. Korgel, Konstantin Sokolov, and Adela Ben-Yakar. "Two-photon luminescence imaging of cancer cells using moleculary targeted gold nanorods," Nano Letters, v.7, 2007, p. 941.

Please report errors in award information by writing to: awardsearch@nsf.gov.