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Award Abstract #0608892
NER: Nano-Biodevices for Reliable, Long-Term Stimulation and Recording of Neural Activity
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
June 27, 2006 |
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| Latest Amendment Date: |
June 27, 2006 |
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| Award Number: |
0608892 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
July 15, 2006 |
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| Expires: |
June 30, 2007 (Estimated) |
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| Awarded Amount to Date: |
$129994 |
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| Investigator(s): |
Latika Menon l.menon@neu.edu (Principal Investigator)
Srinivas Sridhar (Co-Principal Investigator)
Donald O'Malley (Co-Principal Investigator)
Mehmet Dokmeci (Co-Principal Investigator)
Armen Stepanyants (Co-Principal Investigator)
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| Sponsor: |
Northeastern University
360 HUNTINGTON AVE
BOSTON, MA 02115 617/373-5600
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| NSF Program(s): |
NANOSCALE: EXPLORATORY RSRCH,
NANOSCALE: INTRDISCPL RESRCH T
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| Field Application(s): |
0000099 Other Applications NEC
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| Program Reference Code(s): |
OTHR, 1676, 004E, 0000
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| Program Element Code(s): |
1676, 1674
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ABSTRACT
0608892
Menon
The goal of this NER application is to develop nano-biodevices for recording and stimulating nerves that are reliable and long lasting. This exploratory proposal addresses some of the critical issues entailed. These issues include gold nano-wire size, cell growth and motion artifacts, and cell viability at the electrode-cell interface. The research plan calls for fabrication of an array of nano-wires in three sizes ranging of 50, 100, and 200 nm. Measurements will be performed by culturing two types of neural (rat hippocampal and human neuroblastoma) cells onto the surface of Au and peptide conjugated Au nano-wires.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Jesse Silverberg, Sucharita Saha, Zhen Wu, Don O'Malley and Latika Menon. "Development of Au Nanowires for Recording Electrical Activity in Neural Cells," Materials Research Society Symposium. Proc., v.951, 2007, p. 0951-E08-.
Sucharita Saha, Jesse Silverberg, Donald M. O'Malley and Latika Menon. "Nanowire Array Technologies for Investigation of Neural Activity.," Technical Proceedings of the 2007 Nanotechnology Conference and Trade Show, v.2, 2007, p. 795.
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