Award Abstract #0620303
SGER: Biophotonics Techniques for Accurate Diagnosis of Pancreatic Cancer

NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Initial Amendment Date:	April 14, 2006
Latest Amendment Date:	April 14, 2006
Award Number:	0620303
Award Instrument:	Standard Grant
Program Manager:	Leon Esterowitz CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering
Start Date:	July 1, 2006
Expires:	June 30, 2007 (Estimated)
Awarded Amount to Date:	$152412
Investigator(s):	Vadim Backman v-backman@northwestern.edu (Principal Investigator) Randall Brand (Co-Principal Investigator) Hemant Roy (Co-Principal Investigator)
Sponsor:	Northwestern University 633 CLARK ST EVANSTON, IL 60208 847/491-3003
NSF Program(s):	BIOPHOTONICS, IMAGING &SENSING
Field Application(s):	0000099 Other Applications NEC, 0116000 Human Subjects
Program Reference Code(s):	OTHR, 9237, 005E, 0000
Program Element Code(s):	7236

ABSTRACT

0620303

Backman

The following Specific Aims are proposed:

Specific Aim 1: Apply partial wave spectroscopy (PWS) to improve the ability of cytology to

diagnose PC. They will assess fixed cytological samples previously obtained either by ERCP or EUS that were positive and negative to develop prediction rules and, importantly, test it in samples including a subgroup who were cytologically negative but later were diagnosed with pancreatic cancer. The completion of this study will also show the feasibility of a multi-institutional clinical trial where cytology specimens can be reliably exchanged for PWS analysis.

Specific Aim 2: Demonstrate the potential of PWS to correctly identify patients with

concurrent pancreatic cancer based on the analysis of fresh cytological specimens. From the

perspective of future clinical applications, PWS can be potentially used on either fixed or fresh cytological samples. Thus, it is important to compare the diagnostic performance of PWS between these two types of cytological preparations (i.e., fixed vs. fresh cells) and determine which one provides the optimal diagnostic performance.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

Brand, R; Liu, Y; Kim, Y; Kromine, A; Roy, H; Hasabou, N; Shah, D; Backman, V. "Spectral markers of the duodenum can detect pancreatic cancer," GASTROENTEROLOGY, v.130, 2006, p. A36-A36. 

Brand, R; Liu, Y; Sturgis, C; Hasabou, N; Regner, M; Yoon, H; Backman, V. "Feasibility of using biophotonics to assist in cytologic diagnosis of pancreatic cancer," PANCREAS, v.33, 2006, p. 449-449. 

Brand, RE; Subranmanian, H; Sturgis, C; Liu, Y; Turzhitsky, V; Hasabou, N; Polidoro, D; Roy, HK; Backman, V. "A novel highly accurate bio-optical approach for improving the cytologic diagnosis of pancreatic adenocarcinoma(PC)," GASTROENTEROLOGY, v.132, 2007, p. A119-A119. 

Kim, YL; Pradhan, P; Subramanian, H; Liu, Y; Kim, MH; Backman, V. "Origin of low-coherence enhanced backscattering," OPTICS LETTERS, v.31, 2006, p. 1459-1461. 

Liu, Y; Brand, RE; Turzhitsky, V; Kim, YL; Roy, HK; Hasabou, N; Sturgis, C; Shah, D; Hall, C; Backman, V. "Optical markers in duodenal mucosa predict the presence of pancreatic cancer," CLINICAL CANCER RESEARCH, v.13, 2007, p. 4392-4399. 

Roy, HK; Liu, Y; Subramanian, H; Kunte, D; Pradhan, P; Wali, RK; Koetsier, J; Goldberg, MJ; Bogojevic, Z; Backman, V. "Detection of the colorectal cancer (CRC) field effect through partial wave spectroscopic microscopy (Pws)," GASTROENTEROLOGY, v.132, 2007, p. A169-A169. 

Roy, HK; Turzhitsky, V; Kim, YL; Goldberg, ML; Liu, Y; Brand, RE; Hasabou, N; Jameel, M; Backman, V. "Rectal spectral markers: A novel, accurate modality to risk-stratify for colorectal cancer (CRC)," GASTROENTEROLOGY, v.132, 2007, p. A88-A88. 

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