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Award Abstract #0722178
MRI: Acquisition of an NMR Spectrometer to Maintain Active Undergraduate Education and Research Programs
| NSF Org: |
CHE
Division of Chemistry
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| Initial Amendment Date: |
July 24, 2007 |
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| Latest Amendment Date: |
July 24, 2007 |
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| Award Number: |
0722178 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Carlos A. Murillo
CHE Division of Chemistry
MPS Directorate for Mathematical & Physical Sciences
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| Start Date: |
August 1, 2007 |
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| Expires: |
July 31, 2010 (Estimated) |
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| Awarded Amount to Date: |
$342000 |
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| Investigator(s): |
Justin Miller jsmiller@hws.edu (Principal Investigator)
Christine deDenus (Co-Principal Investigator)
Erin Pelkey (Co-Principal Investigator)
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| Sponsor: |
Hobart and William Smith Colleges
337 Pulteney Street
Geneva, NY 14456 315/781-3780
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| NSF Program(s): |
MAJOR RESEARCH INSTRUMENTATION
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| Field Application(s): |
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| Program Reference Code(s): |
OTHR, 9178, 0000
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| Program Element Code(s): |
1189
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ABSTRACT
With this award from the Major Research Instrumentation program (MRI), the Department of Chemistry at Hobart and William Smith Colleges will acquire a 400 MHz nuclear magnetic resonance (NMR) spectrometer. The NMR spectrometer will be utilized to elucidate the structure of molecules during organic synthesis including the synthesis of 1) potential anticancer chemotherapeutics and other peptidic bioconjugates, 2) novel organometallic molecular wire candidates for nanoscale devices and 3) biologically active nitrogen heterocycles.
Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The requested NMR spectrometer will be used to characterize products, identify unknown materials, and determine the three-dimensional geometry of complex structures
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Calandra, N.A.; Cheng, Y.L.; Kocak, K.A.; Miller, J.S.. "Total Synthesis of Spiruchostatin A via Chemoselective Macrocyclization using an Accessible Enantiomerically Pure Latent Thioester," Organic Letters, v.11, 2009, p. 1971.
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