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Award Abstract #0722422
MRI: Development of Ring-Ribbon Resonator Biosensor Instrument
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
August 6, 2007 |
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| Latest Amendment Date: |
August 6, 2007 |
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| Award Number: |
0722422 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
August 15, 2007 |
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| Expires: |
July 31, 2010 (Estimated) |
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| Awarded Amount to Date: |
$443381 |
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| Investigator(s): |
Iwao Teraoka teraoka@poly.edu (Principal Investigator)
Stephen Arnold (Co-Principal Investigator)
Jin Montclare (Co-Principal Investigator)
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| Sponsor: |
Polytechnic University of New York
Six Metrotech Center
Brooklyn, NY 11201 718/260-3550
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| NSF Program(s): |
MAJOR RESEARCH INSTRUMENTATION
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| Field Application(s): |
0000099 Other Applications NEC
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| Program Reference Code(s): |
OTHR, 7237, 7236, 005E, 0000
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| Program Element Code(s): |
1189
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ABSTRACT
CBET-0722422 Teraoka The present proposal is to develop a biosensor instrument to detect and quantify binding of unlabeled receptor biomolecules to surface-immobilized ligands. The instrument will have a sensitivity more than a few orders of magnitude higher compared with state-of-the-art surface plasmon resonance instruments. The instrument will also provide information on the status of bound protein (surface orientation, conformation). The high sensitivity relies on extremely sharp resonance photonic modes, called whispering gallery modes (WGM), in a transparent microsphere less than 0.5 mm across. Light travels the interior side of the sphere surface via total internal reflection to come back in phase after one cycle around the sphere. The light path
becomes slightly longer when biomolecules such as protein bind to the sphere surface, which can be detected as a small red shift of the resonance by an optical fiber touching the sphere. The project will utilize recent discovery and demonstration of enhancing the already high sensitivity of WGM sensor by coating the sphere surface with a sub-wavelength layer of a high refractive index, thus forming a ring ribbon resonator around the sphere for an increased resonance shift.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Iwao Teraoka, Stephen Arnold. "Variational Principle in Whispering Gallery Mode Sensor Response," J. Opt. Soc. Amer. B., v.25, 2008, p. 1038.
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