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Award Abstract #0723935
Collaborative Research: An Arabidopsis Polymorphism Database
| NSF Org: |
DEB
Division of Environmental Biology
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| Initial Amendment Date: |
June 12, 2008 |
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| Latest Amendment Date: |
June 12, 2008 |
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| Award Number: |
0723935 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Nancy J. Huntly
DEB Division of Environmental Biology
BIO Directorate for Biological Sciences
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| Start Date: |
June 15, 2008 |
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| Expires: |
May 31, 2011 (Estimated) |
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| Awarded Amount to Date: |
$635143 |
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| Investigator(s): |
Magnus Nordborg magnus@usc.edu (Principal Investigator)
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| Sponsor: |
University of Southern California
University Park
Los Angeles, CA 90089 213/740-7762
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| NSF Program(s): |
THE 2010 PROJECT
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| Field Application(s): |
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| Program Reference Code(s): |
EGCH, 9169, 1684, 1174
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| Program Element Code(s): |
1684
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ABSTRACT
This project will to generate a community resource for Arabidopsis genetics by integrating several new data sets with the existing A. thaliana genome sequence and those of two closely related species, A. lyrata and Capsella rubella. These data will make it possible to answer fundamental questions about the evolution of A. thaliana, and will facilitate the interpretation of the existing genome sequence. It is analogous to similar efforts to understand human variation and evolution by integrating vast amounts of human polymorphism data with genome sequences from closely related primates like chimpanzee and orangutan. This project will provide a tool for making sense of genetic variation. Understanding how genotypic variation translates into phenotypic variation and how it is structured in populations is fundamental to our understanding of evolution, and has enormous practical implications for human health as well as for plant and animal breeding. The project will also provide training opportunities in bioinformatics and computational biology for multiple students at different levels, areas where there is a nationally recognized shortage of biology students with the requisite quantitative skills.
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