Northwestern University
633 CLARK ST
EVANSTON, IL 60208 847/491-3003
NSF Program(s):
BIOPHOTONICS, IMAGING &SENSING
Field Application(s):
0000099 Other Applications NEC
Program Reference Code(s):
OTHR, 9237, 7237, 005E, 0000
Program Element Code(s):
7236
ABSTRACT
CBET-0733868 Backman Pancreatic cancer (PC) has the worst prognosis of any major cancer, with a five-year survival rate below 5%. The reasons for the lethality of PC relates to its tendency to be
diagnosed at a late stage given that potentially curable stages of disease are often
clinically silent. Survival rate dramatically depends on the stage at which PC is
diagnosed. However, pancreatic cancer is insidious in that the development of symptoms
generally portend unresectable and hence uncurable disease. One of the major hurdles
preventing screening for PC is that essentially any interrogation of the pancreas may lead
to serious complications (~20% complication rate). Thus, finding a pre-screening method in
which patients are risk-stratified would be critical for designing screening strategies.
This project focuses on development of a biophotonics approach (a partial wave spectroscopic microscopic technique), to address this problem.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
A. J. Gomes, H. K. Roy, V. Turzhitsky, Y. Kim, J. D. Rogers, M. J. Goldberg, A. Kromine, M. Jameel, V. Backman. "Rectal Mucosal Microvascular Blood Supply Increase is Associated with Colonic Neoplasia," Clinical Cancer Research, v.15, 2009, p. 3110.
Brand, R; Subramanian, H; Roy, HK; Hasabou, N; Backman, V. "Pilot study examining changes induced in duodenal epithelial cells by different pancreatic diseases as measured by a novel optical imaging modality, single-cell partial wave spectroscopy microscopy," GASTROENTEROLOGY, v.134, 2008, p. A93-A93.
H. K. Roy, A. Gomes, V. Turzhitsky, M. J Goldberg, J. Rogers, S. Ruderman, Y. Kim, A. Kromine, R. E. Brand, M. Jameel, N. Hasabou, V. Backman. "Spectroscopic Microvascular Blood Detection from the Endoscopically Normal Colonic Mucosa: Biomarker for Neoplasia Risk," Gastroenterology, v.135, 2008, p. 1069.
H. K. Roy, V. Turzhitsky, Y. L. Kim, Y. Liu, M. J. Goldberg, R. E. Brand, N. Hasabou, M. Jameel, and V. Backman. "Spectral Slope from the Endoscopically-Normal Mucosa Predicts Concurrent Colonic Neoplasia: A Pilot Ex-Vivo Clinical Study," Diseases of Colon and Rectum, v.51, 2008, p. 1381.
H. Subramanian, P. Pradhan, Y. Liu, I. Capoglu, J. Rogers, H. Roy, R. Brand and V. Backman. "Partial wave microscopic spectroscopy detects sub-wavelength refractive index fluctuations: an application to cancer diagnosis," Optics Letters, v.34, 2009, p. 518.
H. Subramanian, P. Pradhan, Y. Liu, Ilker Capoglu1, X. Li, J. Rogers, A. Heiftez, H. K. Roy, A. Taflove, V. Backman. "Optical Methodology for Detecting Histologically Unapparent Nanoscale Consequences of Genetic Alterations in Biological Cells," PNAS, v.105, 2008, p. 20124.
Kong, SC; Sahakian, A; Taflove, A; Backman, V. "Photonic nanojet-enabled optical data storage," OPTICS EXPRESS, v.16, 2008, p. 13713-13719.
S.-C. Kong, A. Taflove, V. Backman. "Quasi one-dimensional light beam generated by a graded-index microsphere," Optics Express, v.17, 2009, p. 3722.
S.-C. Kong, A. V. Sahakian, A. Taflove, V. Backman. "High-Density Optical Data Storage Enabled by the Photonic Nanojet from a Dielectric Microsphere," JJAP, v.48, 2009, p. 03A008.
Subramanian, H; Brand, R; Deep, PPN; Parikh, V; Hasabou, N; Polidoro, D; Sturgis, C; Backman, V. "Pilot study determining the feasibility of diagnosing pancreatic cancer using single cell partial wave spectroscopy of the duodenal mucosa," PANCREAS, v.35, 2007, p. 429-430.
V. Turshitsky, N. Hasabou, H.K. Roy, V. Backman, R. Brand. "Feasibility of Pancreatic Cancer Detection via Optical Analysis of Duodenal Mucosa," Disease Markers, v.25, 2008, p. 313.
Y. Liu, R. E. Brand, V. Turzhitsky, Y. L. Kim, H. K. Roy, N. Hasabou, C. Sturgis, D. Shah, C. Hall, V. Backman. "Optical Markers in Duodenal Mucosa Predict the Presence of Pancreatic Cancer," Clinical Cancer Research, v.13, 2007, p. 4392.
