Award Abstract #0819686
MRI: Acquisition of a Gemini R Ultra X-ray Diffractometer for Structural Biology and Chemistry

NSF Org:	CHE Division of Chemistry
Initial Amendment Date:	July 11, 2008
Latest Amendment Date:	July 11, 2008
Award Number:	0819686
Award Instrument:	Standard Grant
Program Manager:	Carlos A. Murillo CHE Division of Chemistry MPS Directorate for Mathematical & Physical Sciences
Start Date:	August 1, 2008
Expires:	July 31, 2011 (Estimated)
Awarded Amount to Date:	$410700
Investigator(s):	Roger Rowlett rrowlett@mail.colgate.edu (Principal Investigator) G. Richard Geier, III (Co-Principal Investigator) Anthony Chianese (Co-Principal Investigator)
Sponsor:	Colgate University 13 Oak Drive Hamilton, NY 13346 315/228-7451
NSF Program(s):	MAJOR RESEARCH INSTRUMENTATION
Field Application(s):
Program Reference Code(s):	OTHR, BIOT, 9183, 9178, 0000
Program Element Code(s):	1189

ABSTRACT

With this award from the Major Research Instrumentation program (MRI), Roger Rowlett and colleagues Anthony Chianese and G. Richard Geier III from Colgate University will acquire a single-crystal X-ray diffractometer (XRD) to support research in chemistry and biochemistry including the study of enzyme mechanisms and structure, organometallic catalysis, porphyrinic macrocycles as well as examination of the mechanism of bacterial carbonic anhydrase in E. coli. The instrumentation will also impact undergraduate research, training, and teaching at Colgate and regional undergraduate institutions.

The technique of single-crystal X-ray crystallography allows accurate and precise determination of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of molecules relative to the neighboring molecules. These studies will have an impact in a number of areas ranging from synthetic chemistry to systems of biological interest.

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