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Award Abstract #0300181

An Implantable Integrated System to Restore Vision in the Blind

NSF Org: ECCS
Div Of Electrical, Commun & Cyber Sys
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Initial Amendment Date: May 15, 2003
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Latest Amendment Date: January 4, 2007
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Award Number: 0300181
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Award Instrument: Standard Grant
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Program Manager: Yogesh B. Gianchandani
ECCS Div Of Electrical, Commun & Cyber Sys
ENG Directorate For Engineering
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Start Date: May 15, 2003
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End Date: April 30, 2008 (Estimated)
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Awarded Amount to Date: $186,959.00
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Investigator(s): Wentai Liu wentai@ucla.edu (Principal Investigator)
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Sponsor: University of California-Santa Cruz
1156 High Street
Santa Cruz, CA 95064-1077 (831)459-5278
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NSF Program(s): INTEGRATIVE SYSTEMS
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Program Reference Code(s): 0000, 7234, OTHR
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Program Element Code(s): 1519

ABSTRACT

This proposal by a group of researchers with a proven record of steady and continuous progress toward the realization of a retinal prosthesis for the totally blind will bring about fundamental advances in electronics, telemetry, bioelectromagnetics, and material processing that will enable the realization of a device with over 1,000 electrodes.

Intellectual merit: The proposed project will bring about fundamental advances toward the development of an integrated system compatible with the stringent design specification required for implantation in the human eye. Research will consider novel solutions for wireless bi-directional and high frequency transcutaneous telemetry systems, low power VLSI electronics, stimulating electrode arrays, heterogeneous computational system modeling for performance prediction, and system-on-a-chip fabrication.

Broader impacts: The proposed research effort combines several disciplines toward an effective engineering solution to the problem of blindness. Over 10,000,000 visually impaired worldwide will benefit from this research activity. Further, the team envisions that the proposed research will significantly contribute to a wide range of future wireless implantable biomedical devices. This project will offer a unique research environment with strong interdisciplinary collaborations that will provide graduate and undergraduate students a diversified exposure to innovative biomedical technologies for the 21st century.


PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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W. Liu. "Retinal Implant: Bridging Engineering and Medicine," Digest of International Electron Devices Meeting, 2002, p. 492.

W. Liu, M. Sivaprakasam, P. R. Singh, R. Bashirullah, and G. Wang,. "Electronic Visual Prostheses," Artificial Organs, v.27, 2003, p. 986.

W. Liu. "Intraocular Retinal Prosthesis: A Decade of Learning," Proceedings of 2003 Workshop on Nano Bioelectronics, v.2003, 2003, p. 103.

W. Liu. "Intraocular Retinal Prosthesis: A Decade of Experiences," Proceedings of Symposium on Neuromorphic Computing and Medical Engineering, 2003, p. 11.

W. Liu, M. Humayun, J. Weiland, G. Wang, and A. Kendir. "Microelectronics Retinal Implant Toward Useful Vision for the Blind," UC Systemwide Symposium on Bioengineering,, 2003, p. 66.

W. Liu. "Intraocular Retinal Prosthesis: A Decade of Experiences," Proceedings of The 1st International Symposium on Future Medical Engineering Based on Bio-nanotechnology, 2003, p. 23.

S. C. DeMarco, W. Liu, P. R. Singh, G. Lazzi, M. S. Humayun, and J. D. Weiland. "An Arbitrary Waveform Stimulus Circuit for Visual Prostheses using a Low Area Multibias DAC," IEEE Journal of Solid-State Circuits, v.38, 2003, p. 1679.

R. Bashirullah, W. Liu, Y. Ji, A. Kendir, M. Sivaprakasam, G. Wang, and B. Pundi. "A Smart Bi-directional Telemetry Unit for Retinal Prosthetic Device," Proceedings of the IEEE International Symposium on Circuits and Systems, v.5, 2003, p. 5.

S. C. Demarco, G. Lazzi, W. Liu, J. D. Weiland, and M. S. Humayun. "Computed SAR and Thermal Elevation in a 0.25-mm 2-D Model of the Human Eye and Head in Response to an Implanted Retinal Stimulator ? Part I: Models and Methods," IEEE Transactions on Antennas and Propagation, v.51, 2003, p. 2274.

S. C. Demarco, G. Lazzi, W. Liu, J. D. Weiland, and M. S. Humayun. "Computed SAR and Thermal Elevation in a 0.25-mm 2-D Model of the Human Eye and Head in Response to an Implanted Retinal Stimulator ? Part II: Models and Methods," IEEE Transactions on Antennas and Propagation, v.51, 2003, p. 2286.


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BOOKS/ONE TIME PROCEEDING

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W. Liu and M. Sivaprakasam. "IC Technology Challenges for Implantable Devices", 05/01/2006-04/30/2007, "Future Fab International",  2006, "vol. 20".

W. Liu and M. Sivaprakasam. "IC Technology Challenges for Implantable Devices", 05/01/2007-04/30/2008, "Future Fab International",  2006, "vol. 20".

J. Weiland, M. Humayun, W. Liu, and R. Greenberg. "Stimulated Neural Activity", 05/01/2003-05/01/2004, , W. Finn, and P. LoPresti"Handbook of Neuroprosthetic Methods",  2002, "CRC Press".

J. Weiland, M. Humayun, W. Liu, and R. Greenberg. "Stimulated Neural Activity", 05/01/2006-04/30/2007, , W. Finn, and P. LoPresti"Handbook of Neuroprosthetic Methods",  2002, "CRC Press".

J. Weiland, M. Humayun, W. Liu, and R. Greenberg. "Stimulated Neural Activity", 05/01/2007-04/30/2008, , W. Finn, and P. LoPresti"Handbook of Neuroprosthetic Methods",  2002, "CRC Press".

W. Liu, M. Sivaprakasam, G. Wang, M. Zhou, and M. S. Humayun. "Semiconductor based Implantable Prosthetic Devices", 05/01/2006-04/30/2007, "Wiley Handbook of Biomedical Engineering",  2007, "Wiley Publish".

W. Liu, M. Sivaprakasam, G. Wang, M. Zhou, and M. S. Humayun. "Semiconductor based Implantable Prosthetic Devices", 05/01/2007-04/30/2008, "Wiley Handbook of Biomedical Engineering",  2007, "Wiley Publish".

W. Liu, P. Singh, S. C. DeMarco, R. Bashirullah, M. Humayun, and J. Weiland. "Semiconductor-based Implantable Microsystems", 05/01/2003-05/01/2004, , W. Finn, and P. LoPresti"Handbook of Neuroprosthetic Methods",  2002, "CRC Press".

W. Liu, P. Singh, S. C. DeMarco, R. Bashirullah, M. Humayun, and J. Weiland. "Semiconductor-based Implantable Microsystems", 05/01/2006-04/30/2007, , W. Finn, and P. LoPresti"Handbook of Neuroprosthetic Methods",  2002, "CRC Press".

W. Liu, P. Singh, S. C. DeMarco, R. Bashirullah, M. Humayun, and J. Weiland. "Semiconductor-based Implantable Microsystems", 05/01/2007-04/30/2008, , W. Finn, and P. LoPresti"Handbook of Neuroprosthetic Methods",  2002, "CRC Press".


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