Carlos A. Murillo CHE Division Of Chemistry
MPS Direct For Mathematical & Physical Scien
September 1, 2012
August 31, 2015 (Estimated)
Awarded Amount to Date:
Bruce Macher firstname.lastname@example.org (Principal Investigator)
Ten-Yang Yen (Co-Principal Investigator)
San Francisco State University
1600 Holloway Ave
San Francisco, CA
MAJOR RESEARCH INSTRUMENTATION
Program Reference Code(s):
1108, 1189, 1948, 1982, 6880
Program Element Code(s):
With this award from the Major Research Instrumentation (MRI) program, Professor Bruce Macher from San Francisco State University and colleague Ten-Yang Yen will acquire a benchtop high resolution/accurate mass LC/MS/MS system. The proposal is aimed at enhancing research training and education at all levels. Research areas to be addressed with the new instrument include protein structure, proteomics, biomarker discovery, protein-protein interactions, the development of enzyme inhibitors, the mapping of post-translational modification sites on proteins, the chemistry of singlet oxygen and oxidative methods in organic chemistry, and the chemistry of fulvenes and their application to organic synthesis.
An LC/MS/MS system combines the physical separation capability of liquid chromatography with the mass analysis ability of mass spectrometry. The liquid chromatograph separates a mixture into its molecular components. The separated components flow into the mass spectrometer where they are ionized into a parent ion and fragment ions and their mass/charge ratio are measured. This highly sensitive technique allows determination of the masses and chemical composition of the substances in a complex mixture. The instrumentation provided by this award will provide faculty and students in several departments the opportunity to pursue research projects using state-of-the-art instrumentation. It will also be used in several laboratory courses to train significant numbers of women and students from underrepresented minority groups in the use of this important and widely applied analytical tool.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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Erden, I.; Gronert, S.; Keeffe, J. R.; Ma, J.; Gärtner, C.; Ocal, N.; Soukup, L. L.. "The Effect of Allylic Groups on SN2 Reactivity," J. Org. Chem., v.79, 2014, p. 6410.
Sucu, B. O.; Ocal, N.; Erden, I.. "Direct Synthesis of Imidazolidin-4-ones via Cycloadditions of Imines with a Leuchs? Anyhdride," Tetrahedron Lett., v.56, 2015, p. 2590.
Timpe, L.C.; Li, D.; Yen, T.-Y.; Wong, J.; Yen, R.; Macher, B.A.; Piryatinska, A.. "Mining the Breast Cancer Proteome for Predictors of Drug Sensitivity," J. Proteomics Bioinform., v.8, 2015, p. 204.
Co?kun, N.; , Çetin, M.; Ma, J.; Gronert, S.; Erden, I.. "Pyrrolidine catalyzed reactions of cyclopentadiene with ???-unsaturated carbonmyl compounds: 1,2- versus 1,4-addition," Tetrahedron, v.71, 2015, p. 2636.
Ihsan ERDEN, Jenny SABOL, Ana GUBELADZE, Andrea RUIZ. "An expedient synthesis of 6-vinylfulvene," Turkish Journal of Chemistry, v.NA, 2013, p. 1-6.
Erden, I.; Gronert, S.; Keeffe, J. R.; Ma, J.; Ocal, N.; Gartner, C.; Soukup, L. L.; . "Effect of Allylic Groups on SN2 Reactivity," J Org Chem, v.79, 2014, p. 6410.
Erden, I.; Ma, J.; Gartner, C.; Azimi, S.; Gronert, S.. "Temperature-dependent, competitive 1,3-acyl shift versus decarbonylation of a cyclopropanone intermediate," Tetrahedron, v.69, 2013, p. 5044.
Yen, T. Y.; Haste, N.; Timpe, L. C.; Litsakos-Cheung, C.; Yen, R.; Macher, B. A.. "Using a cell line breast cancer progression system to identify biomarker candidates," J Proteomics, v.96, 2014, p. 173.
Harvey, A.; Yen, T. Y.; Aizman, I.; Tate, C.; Case, C.. "Proteomic analysis of the extracellular matrix produced by mesenchymal stromal cells: implications for cell therapy mechanism," PLoS One, v.8, 2013, p. e79283.
Ten-Yang Yen, Sucharita M. Dutta, Christina Litsakos-Cheung, Alejandro A. Corona, Leslie C. Timpe and Bruce A. Macher. "Overcoming Challenges and Opening New Opportunities in Glycoproteomics," Biomolecules, v.3, 2013, p. 270-286.
Timpe, L. C.; Yen, R.; Haste, N. V.; Litsakos-Cheung, C.; Yen, T. Y.; Macher, B. A.. "Systemic alteration of cell-surface and secreted glycoprotein expression in malignant breast cancer cell lines," Glycobiology, v.23, 2013, p. 1240.