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Award Abstract #1228662

MRI: Acquisition of Instrumentation (LC-MS/MS) for the Trace Analysis of Anthropogenic Organic Compounds and Their Metabolites in Various Complex Matrices

Div Of Chem, Bioeng, Env, & Transp Sys
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Initial Amendment Date: July 31, 2012
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Latest Amendment Date: July 31, 2012
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Award Number: 1228662
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Award Instrument: Standard Grant
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Program Manager: Leon Esterowitz
CBET Div Of Chem, Bioeng, Env, & Transp Sys
ENG Directorate For Engineering
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Start Date: September 1, 2012
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End Date: August 31, 2013 (Estimated)
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Awarded Amount to Date: $237,556.00
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Investigator(s): Guangshu Zhai zhai-guangshu@uiowa.edu (Principal Investigator)
Jerald Schnoor (Co-Principal Investigator)
Keri Hornbuckle (Co-Principal Investigator)
Larry Robertson (Co-Principal Investigator)
Hans-Joachim Lehmler (Co-Principal Investigator)
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Sponsor: University of Iowa
IOWA CITY, IA 52242-1320 (319)335-2123
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Program Reference Code(s): 011E, 056E, 9150
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Program Element Code(s): 1189




P.I.: Guangshu Zhai

This proposed instrument will support the body of research at The University of Iowa on trace organic compounds and their metabolites in the environment and living organisms by increasing capacity and capabilities. This instrument will allow in-depth studies within our ongoing projects, including the transport and fate of hormones in plants (Zhai and Schnoor), hydroxylated metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson) and human blood (Hornbuckle); organic pollutants by extreme flood events (Hornbuckle, Just, Schnoor); PCBs sulfate metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson and Duffel); the enantioselective metabolism of chiral PCBs and their metabolites (Zhai, Schnoor, and Lehlmer); PCB-related compounds in the environment (Hornbuckle, Lehmler, Thorne) and others. All the organic compounds mentioned above have the potential of great harm to our health and environment. All the researchers in this team will use this LC-MS/MS to address many public concerns on the health of environment and human beings. All the findings of these researches will greatly advance our knowledge and understanding of the behavior, fate and toxicological mechanisms of organic pollutants in the environment and alert people to take suitable protective measures.


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