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Award Abstract #1228921

MRI: Acquisition of a high resolution Q-TOF Mass Spectrometer

Division Of Chemistry
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Initial Amendment Date: August 30, 2012
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Latest Amendment Date: August 29, 2013
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Award Number: 1228921
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Award Instrument: Standard Grant
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Program Manager: Carlos A. Murillo
CHE Division Of Chemistry
MPS Direct For Mathematical & Physical Scien
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Start Date: September 1, 2012
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End Date: December 31, 2015 (Estimated)
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Awarded Amount to Date: $332,601.00
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Investigator(s): Mande Holford mholford@hunter.cuny.edu (Principal Investigator)
Clifford Soll (Co-Principal Investigator)
Charles Drain (Co-Principal Investigator)
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Sponsor: CUNY Hunter College
695 Park Avenue
New York, NY 10065-5024 (212)772-4020
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Program Reference Code(s): 1108, 1189, 1982, 5913, 7237, 7298
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Program Element Code(s): 1189, 7298


With this award from the Major Research Instrumentation (MRI) program, Professor Mande Holford from CUNY Hunter College and colleagues Charles Drain and Clifford Soll will acquire a high definition quadrupole time-of-flight (Q-TOF) liquid-chromatography mass spectrometer (LC/MS). The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) small molecules; (b) biopolymers; (c) natural products discovery from complex mixtures; (d) combinatorial libraries; (e) biophysics involving intact proteins or enzymatic digests; (f) scaffolds for nanotechnology materials; and (g) functionalized lipids and dyes.

Mass spectrometry vaporizes and ionizes a sample by a variety of methods. The particles (parent and fragment ions) flow into a mass spectrometer where their mass/charge ratios are measured. This highly sensitive technique allows determination of the masses of the particles, their chemical composition and enables one to deduce the structure of the substances in a complex mixture. An LC/MS combines the physical separation capability of liquid chromatography with the mass analysis ability of mass spectrometry. The liquid chromatograph separates a mixture into its molecular components. These components flow into a mass spectrometer where they are ionized into the parent ion and its fragment ions and their masses are measured. The instrumentation provided by this award will provide faculty and students the opportunity to pursue advanced research projects at CUNY-Hunter College. It will be available for use to faculty and students across the campuses in the CUNY system. It will advance the training of many students in the use of this important and widely employed analytical technique and will advance research in chemistry, materials research, nanotechnology and biochemistry.


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He F, Lindqvist C, Harding WW. "Leonurenones A-C: Labdane diterpenes from Leonotis leonurus," Phytochemistry, 2012.

Ponnala S, Harding WW.. "A New Route to Azafluoranthene Natural Products via Direct Arylation,," European J Org Chem., 2013.

See attached PDF for publication list.. "See attached PDF for publication list.," See attached PDF for publication list., 2013.

H.-S. Byun and R. Bittman,. "Practical Multigram-scale Synthesis of 4,6- and 4,8- Sphingadienes, Chemopreventive Sphingoid Bases," Chem. Phys. Lipids, 2012.

See attached document with list of publications.. "See attached document with list of publications.," See attached document with list of publications., v.Listed, 2013, p. Listed.

Long, Y.; She, Z.; Liu, X.; Chen, Y.. "Synthesis of 1-Aminoisoquinolines by Gold(III)- Mediated Domino Reactions from 2-Alkynylbenzamides and Ammonium Acetate," J. Org. Chem., 2013.

Z. Liu and R. Bittman. "Synthesis of C-Glycoside Analogues of ?-Galactosylceramide via Linear Allylic C-H Oxidation and Allyl Cyanate to Isocyanate Rearrangement," Org. Lett., 2012.

P. Upadhyaya, A. Kumar, H.-S. Byun, R. Bittman, J. D. Saba, and S. S. Hecht. "The Sphingolipid Degradation Product trans-2-Hexadecenal Forms Adducts with DNA," Biochem. Biophys. Res. Commun, 2012.

D. M. Carter Ramirez, S. P. Pitre, Y. A. Kim, R. Bittman, and L. Johnston. "Photouncaging of Ceramides Promotes Reorganization of Liquid-Ordered Domains in Supported Lipid Bilayers," Langmuir, 2013.

Takaoka A, Iacovidou M, Hasson TH, Montenegro D, Li X, Tsuji M, Kawamura A.. "Biomarker-guided screening of Juzen-taiho-to, an oriental herbal formulation for
immunostimulation," Planta Med., 2014.

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