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Award Abstract #1229021

MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Undergraduate and Faculty Research

Division Of Chemistry
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Initial Amendment Date: August 31, 2012
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Latest Amendment Date: August 31, 2012
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Award Number: 1229021
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Award Instrument: Standard Grant
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Program Manager: Carlos A. Murillo
CHE Division Of Chemistry
MPS Direct For Mathematical & Physical Scien
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Start Date: September 1, 2012
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End Date: August 31, 2015 (Estimated)
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Awarded Amount to Date: $285,000.00
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Investigator(s): Mary O'Sullivan osulliv1@canisius.edu (Principal Investigator)
Jeremy Steinbacher (Co-Principal Investigator)
Mariusz Kozik (Co-Principal Investigator)
Sarah Evans (Co-Principal Investigator)
Timothy Gregg (Co-Principal Investigator)
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Sponsor: Canisius College
2001 Main Street
Buffalo, NY 14208-1098 (716)888-2103
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Program Reference Code(s): 1108, 1189, 1401, 1982, 6884
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Program Element Code(s): 1189


With this award from the Major Research Instrumentation Program, Professor Mary O'Sullivan from Canisius College and colleagues Mariusz Kozik, Timothy Gregg, Jeremy Steinbacher and Sarah Evans will acquire a 400 MHz NMR spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) development of particle-based contrast agents for fluorine MRI; (b) investigations of organic mechanisms and methodologies (allene cyclopropanation); (c) development of inhibitors of an enzyme (trypanothione reductase) in parasites; (d) studies of the interactions of polyamines with the N-methyl-D-aspartate (NMDA) receptor; (e) investigations of DNA-protein cross-links; (f) studies to elucidate the structures of inorganic complexes (transition-metal substituted heteropolytungstates); and (g) uses of inorganic complexes as photo-activated catalysts for reduction reactions.

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research at Canisius College and neighboring institutions.


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Adam Dannenhoffer, Jerry Baker, Nicholas Pantano, Jessica Stachowski, Derek Zemla, Eva Zurek, Steven Szczepankiewicz and Mariusz Kozik*. "?Dimerization of Cobalt Substituted Keggin Phosphotungstate, [PW11O39Co(X)]5-, in Nonpolar Solvents?," Journal of Coordination Chemistry, v.67, 2014, p. 2830. 

Mary O'Sullivan*, Timothy Durham, Hannah Valdes, Kelly Dauer, Nicholas Karney, Andrew Forrestel, Cyrus Bacchi, Jerome Baker. ""Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities"," Bioorganic and Medicinal Chemistry, v.23, 2015, p. 996. 


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