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Award Abstract #1229165

MRI: Acquisition of GC-MS to Support Basic and Applied Research and to Integrate Research and Education at Saint Cloud State University

Division Of Chemistry
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Initial Amendment Date: August 31, 2012
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Latest Amendment Date: August 31, 2012
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Award Number: 1229165
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Award Instrument: Standard Grant
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Program Manager: Carlos A. Murillo
CHE Division Of Chemistry
MPS Direct For Mathematical & Physical Scien
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Start Date: September 1, 2012
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End Date: August 31, 2015 (Estimated)
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Awarded Amount to Date: $129,809.00
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Investigator(s): Latha Ramakrishnan lramakrishnan@stcloudstate.edu (Principal Investigator)
Michael Jeannot (Co-Principal Investigator)
Mohammad Mahroof-Tahir (Co-Principal Investigator)
Lakshmaiah Sreerama (Co-Principal Investigator)
Mark Mechelke (Co-Principal Investigator)
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Sponsor: St. Cloud State University
720 Fourth Avenue South
St. Cloud, MN 56301-4498 (320)308-4932
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Program Reference Code(s): 1108, 1189, 1401, 1982, 6884
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Program Element Code(s): 1189


With this award from the Major Research Instrumentation (MRI) program, Professor Latha Ramakrishnan from St. Cloud State University and colleagues Michael Jeannot, Mohammad Mahroof-Tahir, Lakshmaiah Sreerama and Mark Mechelke will acquire a gas chromatograph-mass spectrometer system. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) understanding the evolution and function of GABAergic neurotransmission in planaria; (b) determination of serotonin and norepinephrine reuptake inhibitors in the wastewater treatment;(c) verification of a kinetic model for headspace single-drop microextraction; (d) development of bioprocess technologies to produce ethanol from lignocellulosic biomass; and (e) design and synthesis of goniothalamin analogues to explore the natural product mechanism of action.

A gas chromatograph-mass spectrometer vaporizes and separates a multi component mixture which then passes into the mass spectrometer where the components are ionized. The mass spectrometer determines the mass/charge ratio of these particles (parent molecular ion and fragment ions). This highly sensitive technique allows determination of the masses of the particles, their chemical composition and enables one to deduce the structure of the substances in a complex mixture. The instrumentation provided by this award will provide faculty and students the opportunity to pursue research projects at St. Cloud University. It will advance the training of many students in the use of this important and widely used analytical technique.


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Mark F. Mechelke; Addison A. Dumke; Sarah E. Wegwerth. "Design and Synthesis of a potential Chemotherapeutic agent using goniothalamin as natural product template," Journal of Undergraduate Chemistry Research, v.12, 2013, p. 47.

Mark F. Mechelke, Jason T. Brethorst, Carina Crookston, Courtney Klinkhammer, Brittany N. Miller, Curtis Payne, Makenzie Pilsbury, Christina R. Ringsmuth, and Moriah Traut. "Design and Synthesis of a Novel Alpha-Methylene Lactone Chemotherapeutic Agent," Journal of Undergraduate Chemistry Research, v.13, 2014, p. 12.

Mark F. Mechelke, Addison A. Dumke, and Sarah E. Wegwerth. "Design and Synthesis of a Potential Chemotherapeutic Agent Using Goniothalamin as a Natural Product Template," Journal of Undergraduate Chemistry Research, v.12, 2013, p. 47.


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