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Award Abstract #1229562

Acquisition of a Multimode Spectrophotometer by Elon University to Enhance Undergraduate Research and Teaching in Chemistry and Biochemistry.

NSF Org: CHE
Division Of Chemistry
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Initial Amendment Date: August 31, 2012
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Latest Amendment Date: August 31, 2012
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Award Number: 1229562
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Award Instrument: Standard Grant
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Program Manager: Carlos A. Murillo
CHE Division Of Chemistry
MPS Direct For Mathematical & Physical Scien
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Start Date: September 1, 2012
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End Date: August 31, 2015 (Estimated)
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Awarded Amount to Date: $38,685.00
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Investigator(s): Victoria Moore vmoore3@elon.edu (Principal Investigator)
Karl Sienerth (Co-Principal Investigator)
Kathryn Matera (Co-Principal Investigator)
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Sponsor: Elon University
2610 Campus Box
Elon, NC 27244-9423 (336)278-6603
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NSF Program(s): MAJOR RESEARCH INSTRUMENTATION
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Program Reference Code(s): 1108, 1189, 1982, 9156
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Program Element Code(s): 1189

ABSTRACT

With this award from the Major Research Instrumentation (MRI) program, Professor Victoria Moore from Elon University and colleagues Karl Sienerth and Kathryn Matera will acquire a multimode quad-monochromator plate reader spectrophotometer. The proposal is aimed at enhancing research training and education, especially in areas such as (a) peptide aggregates; (b) protein-protein binding; (c) biochemical changes to mitochondria during apoptosis; and (d) quantitative measurements of environmental and explosive compounds.

This award will provide a multimode spectrophotometer to make absorbance, fluorescence and luminescence measurements on various samples. These are standard spectroscopy techniques used to assay small volumes of solutions in chemistry and biochemistry. Reactions can be followed and quantities of materials determined. This acquisition will provide a basic instrument for current biochemistry and chemistry research by faculty and undergraduate students. Students will be trained to use the most up-to-date assays and technologies which they will encounter after graduation.


PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Bedard M, Giffear KA, Ponton L, Sienerth KD, Del Gaizo Moore V.. "Characterization of binding between 17?-estradiol and estriol with humic acid via NMR and biochemical analysis.," Biophysical Chemistry, v.189, 2014, p. 1. 

Fischer, A.*, Mansfield Matera, K.. "Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines.," Neurochem Res., v.40, 2015, p. 1341. 

Lampl, T., Davis, T. Crum, J.A., Milligan, C. and Del Gaizo Moore, V.. "Isolation and functional analysis of mitochondria from cultured cells and mouse tissue.," Journal of Visual Experimentation, v.97, 2015, p. e52076. 

Bedard, M.E., Giffear, K.A., Ponton, L., Sienerth, K., and Del Gaizo Moore, V.. "Characterization of binding between 17?-estradiol and estriol with humic acid via NMR and biochemical analysis.," Biophysical Chemistry, v.189, 2014, p. 1.

 

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