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Award Abstract #1229808

MRI: Development of a Stimulated Scattering Microscope for Cell Imaging

NSF Org: CBET
Div Of Chem, Bioeng, Env, & Transp Sys
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Initial Amendment Date: August 14, 2012
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Latest Amendment Date: August 14, 2012
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Award Number: 1229808
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Award Instrument: Standard Grant
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Program Manager: Leon Esterowitz
CBET Div Of Chem, Bioeng, Env, & Transp Sys
ENG Directorate For Engineering
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Start Date: August 15, 2012
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End Date: July 31, 2016 (Estimated)
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Awarded Amount to Date: $385,374.00
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Investigator(s): Gregory Faris gregory.faris@sri.com (Principal Investigator)
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Sponsor: SRI International
333 RAVENSWOOD AVE
Menlo Park, CA 94025-3493 (650)859-2651
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NSF Program(s): MAJOR RESEARCH INSTRUMENTATION
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Program Reference Code(s): 005E
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Program Element Code(s): 1189

ABSTRACT

ABSTRACT

The objective of the proposed study is to develop a new type of nonlinear scattering microscopy based on stimulated Rayleigh/Brillouin scattering that will enable measurement of thermal and elastic properties of cells. A central part of this work is assembly of a novel laser system that will provide very rapid tuning and excellent noise properties. In this effort SRI will (1) assemble the laser system, (2) combine the laser system with its associated electronics, and (3) evaluate instrument performance and operation through imaging of cells. This work will bring a new type of nonlinear microscopy to biology and medical research that will complement existing nonlinear microscopy techniques, including multiphoton microscopy using fluorescence, second-harmonic and third harmonic generation, coherent anti-Stokes Raman (CARS) microscopy, and four-wave mixing. SRI has recently developed new advances in stimulated Rayleigh/Brillouin scattering that will enable rapid imaging of cells without causing damage to the cells. The microscope SRI proposes to develop will allow a new look at effects such as signal transduction through mechanical forces, cell motility, cell division, and other aspects involving changes in cellular viscoelastic properties.

 

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