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Award Abstract #1257796

Evolution of venom proteins in sea anemones (Cnidaria: Anthozoa: Actiniaria)

NSF Org: DEB
Division Of Environmental Biology
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Initial Amendment Date: March 5, 2013
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Latest Amendment Date: March 5, 2013
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Award Number: 1257796
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Award Instrument: Standard Grant
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Program Manager: Simon Malcomber
DEB Division Of Environmental Biology
BIO Direct For Biological Sciences
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Start Date: March 1, 2013
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End Date: February 28, 2017 (Estimated)
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Awarded Amount to Date: $450,001.00
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Investigator(s): Marymegan Daly daly.66@osu.edu (Principal Investigator)
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Sponsor: Ohio State University
Office of Sponsored Programs
Columbus, OH 43210-1016 (614)688-8735
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NSF Program(s): PHYLOGENETIC SYSTEMATICS
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Program Reference Code(s): 9169, EGCH
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Program Element Code(s): 1171

ABSTRACT

The earliest occurrence of venom within the animal tree of life is in Cnidaria, the group that includes corals, sea anemones, and jellyfish. In cnidarians, venom is delivered via microscopic intracellular structures called nematocysts, and is implicated a broad array of physiological functions. The venom of sea anemones is more biochemically stable than that of other cnidarians, and broad-scale studies of its biochemistry and toxicology have shown remarkable diversity in venom proteins. Because the functional specialization of the sea anemone body depends largely on the distribution of nematocysts, the diversification of nematocysts and its venom have likely contributed to the diversification of these animals. Venom itself has been the target of evolutionary change in lineages in which former prey or predators like fish, crabs, or snail have evolved a symbiotic relationship.

Venom mediates interactions between sea anemones and the rest of their communities: it defends them from predators, helps them gain prey, and is modified to support symbioses. Understanding the evolution of venom will impact our ability to predict the reactivity and function of venoms within the groups, but will also help us understand how interactions between organisms become codified in genes and how these genes change in response to changes in the organismal interactions.


PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Jason Macrander
Mercer Brugler
Marymegan Daly. "A RNA-seq approach to identify putative toxins from acrorhagi in aggressive and non-aggressive Anthopleura elegantissima polyps.," BMC Genomics, v.16, 2015, p. 221.

Macrander, JM,
Broe, M,
Daly M.. "Multi-copy venom genes hidden in de novo transcriptome assemblies, a cautionary tale with the snakelocks sea anemone Anemonia sulcata (Pennant, 1977).," Toxicon, v.108, 2015, p. 194.

Felipe Zapata, Freya E Goetz, Stephen A Smith, Mark Howison, Stefan Siebert, Samuel H Church, Steven M Sanders, Cheryl Lewis Ames, Catherine S McFadden, Scott C France, Marymegan Daly, Allen G Collins, Steven HD Haddock, Casey W Dunn, Paulyn Cartwright. "Phylogenomic analyses support traditional relationships within Cnidaria," PLoS One, v.10, 2015, p. e0139068.

 

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