text-only page produced automatically by LIFT Text Transcoder Skip all navigation and go to page contentSkip top navigation and go to directorate navigationSkip top navigation and go to page navigation
National Science Foundation Home National Science Foundation - Biological Sciences (BIO)
Molecular and Cellular Biosciences (MCB)
design element
MCB Home
About MCB
Funding Opportunities
Awards
News
Events
Discoveries
Publications
Career Opportunities
Examples of Broader Impacts
Supplements & Other Opportunities
See Additional MCB Resources
View MCB Staff
BIO Organizations
Biological Infrastructure (DBI)
Environmental Biology (DEB)
Emerging Frontiers (EF)
Integrative Organismal Systems (IOS)
Molecular and Cellular Biosciences (MCB)
Proposals and Awards
Proposal and Award Policies and Procedures Guide
  Introduction
Proposal Preparation and Submission
bullet Grant Proposal Guide
  bullet Grants.gov Application Guide
Award and Administration
bullet Award and Administration Guide
Award Conditions
Other Types of Proposals
Merit Review
NSF Outreach
Policy Office
Additional MCB Resources
BIO Reports
BIO Dear Colleague Letters
Interdisciplinary Research
Merit Review
Merit Review Broader Impacts Criterion: Representative Activities
Image Credits
Other Site Features
Special Reports
Research Overviews
Multimedia Gallery
Classroom Resources
NSF-Wide Investments

Email this pagePrint this page

Discovery
New Method Will Aid Genome Researchers

Computer program helps scientists perform genome-wide analyses systematically and fast

Gene networks cartoon

A new computer program aids in genome-wide analyses
Credit and Larger Version

February 10, 2005

Complete understanding of how an organism operates requires more than just knowing the DNA sequence of its genome, it necessitates insight into how an organism’s genetic network functions in sync. An arduous task to say the least, but it's what drives the research of Princeton University’s Saeed Tavazoie.

Tavazoie makes predictions about gene function not just gene by gene, but throughout an organism's entire genome. As an added bonus, he has developed a program that can perform the analysis in a few minutes on a laptop computer, avoiding the need for costly computer clusters often associated with genome-wide studies. 

Today’s improved techniques have made genome sequencing routine. With new reports coming out all the time, scientists can now use Tavazoie’s procedure, which identifies the genetic on/off switches in a genome, to quickly compare two genomes and glean information about how related two species are. Already,  Tavazoie has discovered that organisms as diverse as flies and mammals share many similarities in genetic control.

“Our network-level conservation approach can easily be applied to any pair of genomes.  In fact, we are finding very strong conservation of regulatory elements across all multicellular species – meaning, many of the same control mechanisms are used by seemingly unrelated organisms,” says Tavazoie.

Tavazoie’s research is part of NSF’s prestigious Faculty Early Career Development (CAREER) program.  This program supports the early career-development of those researcher-educators who are deemed most likely to become the academic leaders of the 21st century.

The work was published in the Jan. 26, 2005, issue of Genome Biology.

-- Randy Vines

Related Programs
Faculty Early Career Development (CAREER) Program

Years Research Conducted
2004 - 0

border=0/


Email this pagePrint this page
Back to Top of page