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Discovery
Micro Pills Could Deliver Drugs on Demand

Temperature-sensitive capsules release chemicals at tightly controlled rates

Vesicle membranes that collapse when cooled may someday deliver minute payloads of medicines.

Vesicle membranes that collapse when cooled may someday deliver minute payloads of medicines.
Credit and Larger Version

March 27, 2006

Researchers have now crafted tiny, hollow capsules out of lipids--water-repellant molecules in the same family as fats and oils--that crumple and collapse when cooled below body temperature. The collapse squeezes out whatever chemicals are inside the miniscule ball in a controlled manner that could one day deliver drugs to the human body or improve cosmetics.

Developed by physicist and NSF (Faculty Early Career Development Program (CAREER) awardee Sahraoui Chaieb and his colleagues at the University of Illinois at Urbana-Champaign, the capsules range in size from 10 to 100 micrometers (millionths of a meter) across.

For now, the capsules are in the earliest stages of development and not yet ready for medical use, although the researchers are discussing potential applications of the technology with a cosmetics company.

Before the capsules can be used to deliver medicine, the researchers say they must first develop a mechanism to cool the tiny pills without endangering surrounding body tissues.

The research was published in the Feb. 17 issue of Physical Review Letters.

See the full university press release at the link below.

--Josh Chamot

Investigators
Sahraoui Chaieb

Related Institutions/Organizations
University of Illinois at Urbana-Champaign

Locations
Illinois

Related Programs
Faculty Early Career Development (CAREER) Program

Related Awards
#0238874 CAREER: Pathways to in situ Medication: Liposomal Encapsulation, Transport in Microchannels and Delivery via Liposomal Membrane Crumpling

Total Grants
$402,949

Related Websites
University of Illinois press release: http://www.engr.uiuc.edu/news/?xId=067608800672
Sahraoui Chaieb's homepage: http://www.mie.uiuc.edu/content/about/directory/profile.php?user_id=13

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