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News From the Field

Bone's Material Flaws Lead to Disease


August 4, 2009

a healthy (top) and unhealthy (bottom) fibril The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon. Full Story

Source
Massachusetts Institute of Technology

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