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News From the Field

Penn study: Protein that protects nucleus also regulates stem cell differentiation


August 29, 2013

smoothed nuclear lamina on stiff matrix The human body has hundreds of different cell types, all with the same basic DNA, and all of which can ultimately be traced back to identical stem cells. Despite this fundamental similarity, a bone cell has little in common with a brain cell when it comes to appearance or function. The fact that bone is rigid and mechanically distinct from soft fat or brain had been speculated to play some role in differentiation to new cells in those parts of the body, but mechanisms have been unclear. Full Story

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University of Pennsylvania

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