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Penn researchers show nuclear stiffness keeps stem cells and cancer cells in place


February 24, 2014

Dennis Discher Adult stem cells and cancer cells have many things in common, including an ability to migrate through tiny gaps in tissue. Both types of cells also experience a trade-off when it comes to this ability: Having a flexible nucleus makes migration easier but is worse at protecting the nucleus' DNA compared to a stiffer nucleus. Nuclear proteins that regulate nuclear stiffness are therefore thought to control processes as diverse as tissue repair and tumor growth. Full Story

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University of Pennsylvania

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