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Researchers advance DNA as a storage material

Future of digital memory storage may be in chemically synthesized DNA

DNA molecule that is methylated on both strands

The future of digital memory storage may be in chemically synthesized DNA.


May 13, 2021

The color of a person's eyes, the thickness of a potato's skin, the shape of a flower: What do these seemingly disparate elements have in common? They are all shaped by DNA, which carries the genetic instructions that shape life. What if DNA could encode more than genetic information, such as digital archival data?

It might sound like something out of a science fiction movie, but in a U.S. National Science Foundation-funded study published in Nature Communications, researchers at Boise State University revealed that the future of digital memory storage may be found in the programmable qualities of chemically synthesized DNA.

"We are taking advantage of the information density and programmability of DNA as a memory material," explained Boise State materials scientist and engineer Will Hughes.

This innovation, dubbed Nucleic Acid Memory, or NAM, harnesses the quaternary code of DNA (adenine, guanine, cytosine, thymine) to reliably store information well beyond the predicted lifetimes of traditional memory materials that make up hard-drives, solid-state drives and magnetic tape.

Led by Hughes and Boise State scientist George Dickinson, the team was able to encode digital information into DNA, read it back using an optical microscope, and perform error correction on the data to ensure the integrity. The technique did not require sequencing technology, which historically has been necessary to read DNA information.

"We think of DNA as something that can store genetic information, but now we know so much about the molecular biology of DNA that we can manipulate it, and instead of using it to store genetic information, we can use it as a building material," said Dickinson.

Added Usha Varshney, a program director in NSF's Directorate for Engineering, "This digital information storage in chemically synthesized DNA brings us closer to the reality of practical use than we might have thought possible."

--  NSF Public Affairs, researchnews@nsf.gov