Genetic Mechanisms

Name Email Phone Room
Arcady  Mushegian (703) 292-8528  E12475  
Karen  C. Cone (703) 292-4967  E12477  
Michael  Weinreich (703) 292-7582  E12467  
Anthony  G. Garza (703) 292-8440  Offsite  


 Apply to NSF 17-589

The cluster supports inventive studies seeking to address fundamental mechanisms involved in the evolution, organization, dynamics, and utilization of genetic information within cellular systems. Projects are encouraged that employ theoretical, computational, and experimental approaches to integrate structural, biochemical, genetic, and "omic" (genome, transcriptome, interactome, phenome, etc.) data to discover rules that help explain the relationship of genotype to molecular phenotype. Interdisciplinary research is encouraged, and when driven by compelling questions, development and use of innovative in vivo and in vitro technical and computational approaches are welcome.

Funding priority is given to proposals that employ quantitative frameworks and promise high-impact advances in the following areas:

  • Chromatin- and RNA-mediated regulatory mechanisms.
  • Dynamics and spatiotemporal coordination of genome replication, DNA repair, chromatin modification, transcription, and translation.
  • Origin and evolution of genetic polymers, including DNA, RNA and proteins.