Genetic Mechanisms

Name Email Phone Room
Manju  Hingorani 703-292-7323  E12469  
Karen  C. Cone (703) 292-4967  E12477  
Candi Phoebe  Lostroh (703) 292-7145  E12474  
Arcady  Mushegian (703) 292-8440  On Professional Leave  
Stephen  DiFazio (703) 292-4517  E12472  


Apply to NSF 21-509

The cluster supports inventive studies seeking to address fundamental mechanisms involved in the evolution, organization, dynamics, and utilization of genetic information within cellular systems. Projects are encouraged that employ theoretical, computational, and experimental approaches to integrate structural, biochemical, genetic, and "-omic" data to discover rules that help explain the maintenance and expression of genomes. Interdisciplinary research is encouraged, and when driven by compelling questions, development and use of innovative in vivo and in vitro technical and computational approaches are welcome.

Funding priority is given to proposals that employ quantitative frameworks and promise high-impact contributions and significant advances in the following areas:

  • Chromatin- and RNA-mediated regulatory mechanisms
  • Dynamics and spatiotemporal coordination of genome replication, DNA repair, chromatin modification, transcription, and translation.
  • Origin and evolution of genetic polymers, including DNA, RNA and proteins.