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March 24, 2020

Confocal microscopy image of human embryonic kidney cells

Confocal microscopy image of human embryonic kidney cells. Nanoparticles filled with human immunoglobulin were delivered to the cells. The cell nucleus is blue, endosomes (which sequester materials taken up by cells) are labeled in pink, and the immunoglobulin proteins are labeled with a green fluorescent tag. The nanoparticle's cargo has spread widely through most of the cells (green) without it being trapped in endosomes.

[Research supported by National Science Foundation Graduate Research Fellowships DGE 0707427 and DGE 1232825]

Learn more about this research in the Johns Hopkins news story Little size holds big impact: Johns Hopkins scientists develop nanocontainer to ship titan-size gene therapies and drugs into cells. (Date image taken: unknown; date originally posted to NSF Multimedia Gallery: March 24, 2020)

Credit: Yuan Rui, Johns Hopkins Medicine,Johns Hopkins University

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