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Structural model of type II topoisomerase

Model illustrating a Type II topoisomerase protein encompassing a section of DNA

Model illustrating a Type II topoisomerase protein encompassing a section of DNA (surrounded by a wreath of blue).

Topoisomerases are essential for untangling chromosomal DNA, which they do by cutting fragments and resealing them. As depicted by molecular models, pieces of DNA are ushered through the topoisomerase enzyme protein, which appears as a clamp with two sets of jaws at opposite ends, connected by multiple joints.

This research was performed in the lab of James Berger of the Whitehead Institute. (Date of Image: Unknown)

Credit: ©Whitehead Institute for Biomedical Research

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