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Images of a mouse hindquarter containing a tumor.

Images of a mouse hindquarter containing a tumor.

Images of a mouse hindquarter containing a tumor. The first image is a regular photograph, and the other three, taken in a time series after injecting the mouse with dextran-coated silicon nanoparticles, show intensity color maps of the red emission channel. The red color shows the brightest fluorescence of the silicon nanoparticles, which initially localize in the tumor and then slowly disappear. Time after injection is indicated in the upper left of each image. The tumor is an MDA-MB-435 xenograft. Note that a strong signal is observed in the tumor two hours after injection, indicating significant passive accumulation by the EPR effect.

Credit: Ji-Ho Park, UCSD

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