New ultrasensitive detection platform
An artistic illustration showing an ultrasensitive detection platform called SLIPSERS -- slippery liquid infused porous surface-enhanced Raman scattering. An aqueous or oil droplet containing gold nanoparticles and captured analytes is allowed to evaporate on a slippery substrate, leading to the formation of a highly compact nanoparticle aggregate for surface enhanced Raman scattering detection.
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Researchers at Penn State have developed a new technique that combines the ultrasensitivity of surface-enhanced Raman scattering (SERS) with a slippery surface. The technique will make it feasible to detect single molecules from a number of chemical and biological species, whether gaseous, liquid or solid. This combination of slippery surface and laser-based spectroscopy will open new applications in analytical chemistry, molecular diagnostics, environmental monitoring and national security.
The research was funded by a U.S. National Science Foundation Faculty Early Career Development (CAREER) program award (grant CMMI 1351462).
Learn more in the Penn State news story Single molecule detection of contaminants, explosives or diseases now possible. (Date image taken: December 2015; date originally posted to NSF Multimedia Gallery: July 12, 2016)
Credit: Shikuan Yang, Birgitt Boschitsch Stogin and Tak-Sing Wong, The Pennsylvania State University
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