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Smart thread collects diagnostic data
Researchers have integrated nanoscale sensors, electronics and microfluidics into threads that can be sutured through multiple layers of tissue to gather diagnostic data wirelessly in real time. In this graphic, threads penetrate multiple layers of tissue to sample interstitial fluid and direct it to sensing threads that collect data such as pH and glucose levels. Conductive threads then deliver the data to a flexible wireless transmitter sitting on top of the skin.
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Researchers led by Tufts University engineers have for the first time, integrated nanoscale sensors, electronics and microfluidics into threads ranging from simple cotton to sophisticated synthetics that can be sutured through multiple layers of tissue to gather diagnostic data wirelessly in real time.
The research suggests that the thread-based diagnostic platform could be an effective substrate for a new generation of implantable diagnostic devices and smart wearable systems.
Using a variety of conductive threads that were dipped in physical and chemical sensing compounds and connected to wireless electronic circuitry, the researchers created a flexible platform that they sutured into tissue in rats as well as in vitro.
The threads collect data on tissue health (e.g., pressure, stress, strain and temperature), pH and glucose levels that can be used to determine such things as how a wound is healing, whether infection is emerging or whether the body’s chemistry is out of balance. The results are transmitted wirelessly to a cellphone and computer. The 3-D platform can conform to complex structures such as organs, wounds or orthopedic implants.
Further study is needed in a number of areas, including investigation of long-term biocompatibility, but the researchers say the initial results raise the possibility of optimizing patient-specific treatments.
The research was supported in part by the National Science Foundation Emerging Frontiers in Research and Innovation program (grant EFRI 12-40443).
To learn more, see the Tufts news story Researchers invent 'smart' thread that collects diagnostic data when sutured into tissue. (Date image taken: July 2016; date originally posted to NSF Multimedia Gallery: Oct. 4, 2016)
Credit: Nano Labs, Tufts University School of Engineering
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