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Press Release 13-186
NSF-funded center will use X-ray lasers to transform the field of structural biology and pharmaceutical development

Buffalo center brings world-class NSF research center to mid-Atlantic

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Illustration from computer simulation predicting how 2 regions of a eukaryotic enzyme bind to tRNA.

This computer simulation predicts how two regions of a eukaryotic enzyme come together to bind to tRNA. The simulation reveals a hinge motion in the appended domain of Gln4 that has been shown to be critical to properly recognizing the tRNA molecule and (eventually) identifying new drugs.

Credit: Edward Snell, Hauptman-Woodward Medical Research Institute


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Illustration of protein structure of an eukaryotic enzyme using X-ray crystallography

Using X-ray crystallography, Hauptman-Woodward Medical Research Institute researchers solved the protein structure of this eukaryotic enzyme involved in decoding DNA into protein, even though data on an important region in the enzyme was missing.

Credit: Edward Snell, Hauptman-Woodward Medical Research Institute


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