News From the Field
Penn Researchers Show That Protein Unfolding is Key for Understanding Blood Clot Mechanics
August 6, 2009
Fibrin, the chief ingredient of blood clots, is a remarkably versatile polymer. On one hand, it forms a network of fibers--a blood clot--that stems the loss of blood at an injury site while remaining pliable and flexible. On the other hand, fibrin provides a scaffold for thrombi, clots that block blood vessels and cause tissue damage, leading to cardiovascular disease. The answer is a process known as protein unfolding.
University of Pennsylvania School of Medicine
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