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Discovery
Placing Landmarks on the Genome Map
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The schematic diagram shows human chromosome 21 with a small region outlined in red. The main rectangle below is a close-up of the outlined region, showing the binding locations of three transcription factors along the chromosome.
Credit: Courtesy of Vishy Iyer |
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Representation of allele-specific and non-allele-specific single nucleotide polymorphisms (SNPs) across the CTCF binding motif (17). The y-axis indicates the difference between the two as a percentage of normalized total SNPs. Higher bars indicate an increased representation of allele-specific SNPs relative to other positions, which tend to occur at conserved positions.
Credit: McDaniell, R., et al. 2010. Heritable Individual-Specific and Allele-Specific Chromatin Signatures in Humans. Science 328 (5975): 235-239. |
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